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자료유형
학술저널
저자정보
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology 제25권 제4호
발행연도
2013.1
수록면
410 - 416 (7page)

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Background: Staphylococcus aureus (SA) has peculiar abilities to colonize the skin in atopic dermatitis (AD)patients. Objective: We sought to determine the colonization rates of SA in acute and chronic skin lesions of AD patients, to find any difference in colonization rates according to age and to find the influences of total immunoglobulin E (IgE) and eosinophil counts to the colonization of SA. Methods: We evaluated the total IgE level and eosinophil counts, and cultured SA from the skin lesions of 687 AD patients (131 acute and 556 chronic skin lesions) and 247control urticaria patients (July 2009 to November 2010;Samsung Medical Center Dermatology Clinic, Seoul, Korea). Results: The SA colonization rates were 74%, 38% and 3%in acute, chronic skin lesions and control skin, respectively,and they were increased with age in AD patients. The colonization rate in chronic skin lesions was higher in the high IgE/eosinophilia groups as compared to the normal IgE/eosinophil groups. Conclusion: The SA colonization rate was higher in AD patients and especially in acute lesions,and had a tendency to increase with age. As the colonization rates were only higher in the high IgE/eosinophilia groups of chronic skin lesions, we suggested that SA may invade the skin through barrier defects in acute skin lesions, but the colonization in chronic lesions may be orchestrated through many different factors.

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