지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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To characterize the relationship between the stage of hepatic fibrosis and bioimpedance, several electric parameters were estimated in rats with CCl_4-induced liver fibrosis. Thirty three Sprague-Dawley rats were intraperitoneally injected with a CCl_4-mineral oil mixture (1:1, 0.2 mL/100 g) twice a week for 8 weeks. The resistance(R), reactance(X), impedance(Z), and dissipation factor(D) between 1 kHz and 100 kHz were then evaluated in the livers of the rats under pentobarbital anesthesia using an HP4294A Impedance Analyzer. The rats were killed 2, 4, 6, and 8 weeks later, and their livers were classified in accordance with Ishak’s scoring system. R, X, and Z changed in accordance with the progression of hepatic fibrosis and the changes were greater at lower frequencies than at higher frequencies. In comparison, the D spectrum was biphasic; D increased initially then decreased with increasing frequency. All of the parameters(R, X, Z, and D) changed in accordance with the stage of fibrosis in the livers, but D changed specifically with the progression of fibrosis. These results indicate that hepatic fibrosis may be evaluated by determining the changes in D.
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참고문헌 (18)
참고문헌 신청
A. Hayasaka / 1998 / Serum markers as tools to monitor liver fibrosis / Digestion 59 : 381 ~ 384
A.P. O’Rouke / 2007 / M / Phys. Med. Biol 52 : 4707 ~ 4719
C. Aube / 1999 / Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis / J. Hepatol 30 : 472 ~ 478
D.K. George / 1999 / Elevated serum type IV collagen:a sensitive indicator of the presence of cirrhosis in haemochromatosis / J. Hepatol 31 : 47 ~ 52
G. Gabbiani / 1975 / Early changes of endothelial clefts after thermal injury / Microvasc. Res 10 : 65 ~ 75
A.P. O’Rouke / 2007 / M / Phys. Med. Biol 52 : 4707 ~ 4719
C. Aube / 1999 / Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis / J. Hepatol 30 : 472 ~ 478
D.K. George / 1999 / Elevated serum type IV collagen:a sensitive indicator of the presence of cirrhosis in haemochromatosis / J. Hepatol 31 : 47 ~ 52
G. Gabbiani / 1975 / Early changes of endothelial clefts after thermal injury / Microvasc. Res 10 : 65 ~ 75
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