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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 252 - 257 (6page)
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It is noted that Dioscorea quinqueloba is a medicinal herb that is widely used to treat cardiovascular disease and is assessed as useful to treat other various medical conditions. The immunopotentiating effects of the protein extract (DQP-1) from Dioscorea quinqueloba were thus formally investigated in vivo under incident of cold stress. In this case study, the spleen and thymus weight in mice was shown to have decreased after a measured exposure to cold stress, while the adrenal gland weight in the mice was shown to have increased. The systematic oral administration of DQP-1 significantly recovered the weight loss of the spleen and suppressed the adrenal gland hypertrophy during the association with cold stress. Additionally, the DQP-1 also restored the ascorbic acid level in the adrenal gland reduced after cold stress. The cold stress exposure lowered the percentage of CD4+ and CD8+ cells in the mouse thymus as determined by the flow cytometric analysis, as well as the levels of some serum immunological cytokines(interleukin-2, interleukin-12, and interferon-γ) in the studied mice. The resulting identified weakened immunity caused by cold stress was also recovered by a treatment with DQP-1. The DQP-1 significantly suppressed the formation of serum enzymes of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, which were systematically elevated during the cold stress episode. These results indicate that DQP-1 can improve immunity in mice that are characteristically weakened under stress.
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참고문헌 (16)
참고문헌 신청
Barbesti S / 2005 / A simplified flow cytometry method of CD4 and CD8 cell counting based on thermoresistant reagents: Implications for large scale monitoring of HIV-infected patients in resource-limited settings / Cytometry B Clin Cytom 68:43~51
Cichon M / 2002 / Delayed effects of cold stress on immune response in laboratory mice / Proc Biol Sci 269:1493~1497
Dantzer R / 1989 / Stress and immunity: an integrated view of relationships between the brain and the immune system / Life Sci 44:1995~2008
Gaidamashvili M / 2004 / Characterization of the yam tuber storage proteins from Dioscorea batatas exhibiting unique lectin activities / J Biol Chem 279:26028~26035
Herbert TB / 1993 / Stress and immunity in humans: A meta-analytic review / Psychosom Med 55:364~379
Cichon M / 2002 / Delayed effects of cold stress on immune response in laboratory mice / Proc Biol Sci 269:1493~1497
Dantzer R / 1989 / Stress and immunity: an integrated view of relationships between the brain and the immune system / Life Sci 44:1995~2008
Gaidamashvili M / 2004 / Characterization of the yam tuber storage proteins from Dioscorea batatas exhibiting unique lectin activities / J Biol Chem 279:26028~26035
Herbert TB / 1993 / Stress and immunity in humans: A meta-analytic review / Psychosom Med 55:364~379
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