지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The family of bile acids belongs to a group of molecular species of acidic steroids with very peculiar biological characteristics.
They are synthesized by the liver from cholesterol through several complementary pathways and secreted into small intestine for the participation in the digestion and absorption of fat. The bile acids are mostly confined to the territories of the so-called enterohepatic circulation, which includes the liver, the biliary tree, the intestine and the portal blood with which bile acids are returned to the liver. In patients with bile acid malabsorption, the amount of primary bile acids in the colon is increased compared to healthy controls. Although the increase in the secondary bile acids including deoxycholic acid, is reported to have the potency to affect tumorigenesis in gastrointestinal tracts, there is no firm evidence that clinically relevant concentrations of the bile acids induce cancer. The list of their physiological roles,as well as that of the pathological processes is long and still not complete. There is no doubt that many new concepts,pharmaceutical tools and pharmacological uses of bile acids and their derivatives will emerge in the near future.
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참고문헌 (24)
참고문헌 신청
Attili AF / 1986 / Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids / Med Hypotheses 19 (1) : 57 ~ 69
Ayaki Y / 1981 / Role of endogenous and exogenous cholesterol in liver as the precursor for bile acids in rats / Steroids 38 (5) : 495 ~ 509
Craddock AL / 1998 / Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter / Am J Physiol 274 (1) : G157 ~ G169
Danielsson A / 1991 / Chronic diarrhoea after radiotherapy for gynaecological cancer: occurrence and aetiology / Gut 32 (10) : 1180 ~ 1187
Fernandez-Banares F / 2007 / Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics / Am J Gastroenterol 102 (11) : 2520 ~ 2528
Ayaki Y / 1981 / Role of endogenous and exogenous cholesterol in liver as the precursor for bile acids in rats / Steroids 38 (5) : 495 ~ 509
Craddock AL / 1998 / Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter / Am J Physiol 274 (1) : G157 ~ G169
Danielsson A / 1991 / Chronic diarrhoea after radiotherapy for gynaecological cancer: occurrence and aetiology / Gut 32 (10) : 1180 ~ 1187
Fernandez-Banares F / 2007 / Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics / Am J Gastroenterol 102 (11) : 2520 ~ 2528
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