지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Purpose: This study aims to investigate how gender-based differences are actually reflected on drug approval.
Methods: Data on gender-based differences of drugs were analyzed by searching PDR (Physician’s Desk Reference) with the keyword, “GENDER”.
Results: There were descriptions related to gender in product directions of 361 drugs in 2009 PDR, out of which 63items actually showed gender-related differences. Drug categories showing comparatively high gender-based differences were nervous system, cardiovascular system, and alimentary tract and metabolism. Pharmacokinetic differences between genders were observed most frequently; compared to men, 32 drugs showed higher absorption while 18 drugs revealed lower clearance in women. There were 2 drugs which gender should be considered before prescribing, and 5 drugs which showed different severity of adverse effects according to gender.
Conclusions: It is necessary to establish domestic policies for drug approval and use which reflects gender-based differences through sufficient researches.
목차
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참고문헌 (20)
참고문헌 신청
/ / Guideline for Study and Evaluation of Gender Differences in the Clinical Evaluation of Drugs, Jul. 1993
/ / PDR® 63edition 2009
/ / Protecting and Advancing Women's Health: The FDA Office of Women's Health Progress Peport 10 years and Beyond…, Mar. 2006
/ / Reflection Paper on Gender Differences in Cardiovascular Diseases, Dec. 2006
/ / Society for Women's Health Research
/ / PDR® 63edition 2009
/ / Protecting and Advancing Women's Health: The FDA Office of Women's Health Progress Peport 10 years and Beyond…, Mar. 2006
/ / Reflection Paper on Gender Differences in Cardiovascular Diseases, Dec. 2006
/ / Society for Women's Health Research
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