지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective: It is to evaluate the drug interaction monitoring program as a pilot project to develop a pharmaceutical care model in a medical intensive care unit and to analyze the influencing factors of drug interactions. Method: Electronic medical records were retrospectively investigated for 116 patients who had been hospitalized in a medical intensive care unit from October to December in 2014. The prevalence of adverse reaction with risk rating higher than ‘D’ was investigated by Lexi-Comp® Online database. The factors related with potential drug interaction and with treatment outcomes were analyzed. Results: The number of patients with a potential interaction of drug combination was 92 (79.3%). Average ages, the length of stay in the intensive care unit and the numbers of prescription drugs showed significant differences between drug interaction group and non-drug interaction group. Opioids (14.4%), antibiotics (7.2%), and diuretics (7.2%) were most responsible drug classes for drug interactions and the individual medications included furosemide (6.4%), tramadol (4.9%), and remifentanil (4.5%). There were 950 cases with a risk rating of ‘C’ (84.6%), 142 cases with a risk rating of ‘D’ (12.6%), and 31 cases with a risk rating of ‘X’ (avoid combination) (2.8%). The factors affecting drug interactions were the number of drugs prescribed (p < 0.0001) and the length of stay at intensive care unit (p < 0.01). The patients in intensive care unit showed a high incidence of adverse reactions related to potential drug interaction. Therefore, drug interaction monitoring program as a one of pharmaceutical care services was successfully piloted and it showed to prevent adverse reaction and to improve therapeutic outcomes. Conclusion: Active participation of a pharmacist in the drug management at the intensive care unit should be considered.
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등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
/ / Lexi-interactTM
Cash JJ / 2009 / Alert fatigue / Am J Health-Syst Pharm 66 (23) : 2098 ~ 2101
Fischer JR. / 1996 / Acute myopathy associated with combined use of corticosteroids and neuromuscular blocking agents / Ann Pharmacother 30 (12) : 1437 ~ 1445
Hasan SS. / 2012 / Impact of pharmacists' intervention on identification and management of drug-drug interactions in an intensive care setting / Singapore Med J 53 (8) : 526
Kim HA / 2014 / A Study on the Improvement of Drug Safety for Pharmaceutical Care Disparities in Korea / In: Fall Symposium of Korean Academy of Social & Managed Care Pharmacy
Cash JJ / 2009 / Alert fatigue / Am J Health-Syst Pharm 66 (23) : 2098 ~ 2101
Fischer JR. / 1996 / Acute myopathy associated with combined use of corticosteroids and neuromuscular blocking agents / Ann Pharmacother 30 (12) : 1437 ~ 1445
Hasan SS. / 2012 / Impact of pharmacists' intervention on identification and management of drug-drug interactions in an intensive care setting / Singapore Med J 53 (8) : 526
Kim HA / 2014 / A Study on the Improvement of Drug Safety for Pharmaceutical Care Disparities in Korea / In: Fall Symposium of Korean Academy of Social & Managed Care Pharmacy
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