지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 151 - 156 (6page)
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초록· 키워드
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Sloan-Kettering virus gene, a product of a cellular protooncogene c-Ski is a unique nuclear pro-oncoprotein and belongs to the Ski/Sno proto-oncogene family. The aim of the present study was to locate Ski protein in rat ovaries in order to find insights into the possible involvement of Ski in follicular development and atresia. Ovaries obtained on the day of estrus were subjected to immunohistochemical analysis for Ski and PCNA in combination with TUNEL. Ski was expressed in granulosa cells that were positive for TUNEL, but negative for PCNA, regardless of the shape and size of the follicles. Expression of Ski in (TUNEL)-positive granulosa cells, but not in(PCNA)-positive granulosa cells, was verified in immature hypophysectomized rats having a single generation of developing and atretic follicles by treatment with equine chorionic gonadotropin(eCG). These results indicate that Ski is profoundly expressed in the granulosa cells of atretic follicles, but not in growing follicles. Based on the present findings, Ski has maybe played plays a role in apoptosis of granulosa cells during follicular atresia.
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참고문헌 (26)
참고문헌 신청
Akiyoshi, S. / 1999 / c-Ski acts as a transcriptional co-repressor in transforming growth factor-b signaling through interaction with smads / J. Biol. Chem 274 : 35269 ~ 3527
Ambrose, MR. / 1995 / Expression of the c-Ski proto-oncogene during cell cycle arrest and myogenic differentiation. DNA / Cell. Biol 14 : 701 ~ 707
Asai, S. / 2002 / Reproductive endocrinology in Hatano high- and low-avoidance rats during the estrous cycle / Endocrine 18 : 161 ~ 166
Barak, Y. / 1993 / Mdm2 expression is induced by wild type p53 activity / EMBO. J 12 : 461 ~ 468
Berk, M. / 1997 / Mice lacking the Ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development / Genes and Development 11 : 2029
Ambrose, MR. / 1995 / Expression of the c-Ski proto-oncogene during cell cycle arrest and myogenic differentiation. DNA / Cell. Biol 14 : 701 ~ 707
Asai, S. / 2002 / Reproductive endocrinology in Hatano high- and low-avoidance rats during the estrous cycle / Endocrine 18 : 161 ~ 166
Barak, Y. / 1993 / Mdm2 expression is induced by wild type p53 activity / EMBO. J 12 : 461 ~ 468
Berk, M. / 1997 / Mice lacking the Ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development / Genes and Development 11 : 2029
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