지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 157 - 163 (7page)
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초록· 키워드
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The male reproduction is precisely controlled by a number of intrinsic and extrinsic factors. These factors usually involve in expressional regulation of various molecules influencing on sperm production in the testis. A number of ways are employed to control the transcription of specific genes, including epigenetic modifications of DNA and histone molecules. DNA methylation of CpG dinucleotides is a commonly used regulatory mechanism for testicular genes associated with the fertility. Previous studies have demonstrated the infertility induced by improper DNA methylation of these genes. In the present research, we attempted to determine transcriptional expression of some of these genes in the rat testis at different postnatal ages using real-time PCR analysis. These genes include neurotrophin 3(Ntf3), insulin-like growth factor II(Igf2), JmjC-domain-containing histone demethylase 2A 1(Jhm2da), paired box 8 transcription factor(Pax8), small nuclear ribonucleoprotein polypeptide N(Snrpn), and 5,10- methylenetetrahydrofolate reductase(Mthfr). The expression levels of Ntf3, Igf2, and Snrpn genes were the highest at the neonatal age, followed by transient decreases at the prepubertal age. Expression of Jhm2da and Mthfr genes were continuously increased from the neonate to 1 year of age. The levels of Pax8 mRNA at the early ages were higher than those at the later ages of postnatal development. These findings suggest that expression of some fertility-associated testicular genes in the rat during postnatal period could be differentially regulated by the control of the degree of DNA methylation.
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참고문헌 (22)
참고문헌 신청
Berensztein, E. B. / 2008 / Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells / Pediatr. Res 63 : 662 ~ 668
Berger, S. L. / 2002 / Histone modifications in transcriptional regulation / Curr. Opin. Genet. Dev 12 : 142 ~ 148
Biermann, K. / 2007 / Epigenetics in male germ cells / J. Androl 28 : 466 ~ 480
Chan, D. / 2010 / Strain-specific defects in testicular development and sperm epigenetic patterns in 5, 10-methy- neteahydrofolate reductase-deficient mice / Endocrinology 15
Colon, E. / 2007 / Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development / Endocrinology 148 : 128 ~ 139
Berger, S. L. / 2002 / Histone modifications in transcriptional regulation / Curr. Opin. Genet. Dev 12 : 142 ~ 148
Biermann, K. / 2007 / Epigenetics in male germ cells / J. Androl 28 : 466 ~ 480
Chan, D. / 2010 / Strain-specific defects in testicular development and sperm epigenetic patterns in 5, 10-methy- neteahydrofolate reductase-deficient mice / Endocrinology 15
Colon, E. / 2007 / Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development / Endocrinology 148 : 128 ~ 139
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