지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
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- 1 - 7 (7page)
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Background: The Sapsaree (Canis familiaris) is a Korean native dog that is very friendly, protective, and loyal to its owner, and is registered as a natural monument in Korea (number: 368). To investigate large-scale gene expression profiles and identify the genes related to exercise-induced stress in the Sapsaree, we performed whole-transcriptome RNA sequencing and analyzed gene expression patterns before and after exercise performance.
Results: We identified 525 differentially expressed genes in ten dogs before and after exercise. Gene Ontology classification and KEGG pathway analysis revealed that the genes were mainly involved in metabolic processes, such as programmed cell death, protein metabolic process, phosphatidylinositol signaling system, and cation binding in cytoplasm. The ten Sapsarees could be divided into two groups based on the gene expression patterns before and after exercise. The two groups were significantly different in terms of their basic body type (p ≤ 0.05). Seven representative genes with significantly different expression patterns before and after exercise between the two groups were chosen and characterized.
Conclusions: Body type had a significant effect on the patterns of differential gene expression induced by exercise.
Whole-transcriptome sequencing is a useful method for investigating the biological characteristics of the Sapsaree and the large-scale genomic differences of canines in general.
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참고문헌 (26)
참고문헌 신청
J.H. Ha / 2015 / Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Behavior in Sapsaree Dog (Canis familiaris) / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28(7):936~942
Kim KS / 2001 / Suitability of AFLP markers for the study of genetic relationships among Korean native dogs / Genes Genet Syst 76(4):243~250
Kyung-Do Park / 2012 / Whole transcriptome analyses of six thoroughbred horses before and after exercise using RNA-Seq / BMC Genomics 13(1):473
Stefano Capomaccio / 2013 / RNA Sequencing of the Exercise Transcriptome in Equine Athletes / PLoS ONE 8(12):e83504
Greiner bio-one
Kim KS / 2001 / Suitability of AFLP markers for the study of genetic relationships among Korean native dogs / Genes Genet Syst 76(4):243~250
Kyung-Do Park / 2012 / Whole transcriptome analyses of six thoroughbred horses before and after exercise using RNA-Seq / BMC Genomics 13(1):473
Stefano Capomaccio / 2013 / RNA Sequencing of the Exercise Transcriptome in Equine Athletes / PLoS ONE 8(12):e83504
Greiner bio-one
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