지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Oxidative stress has been reported to be one of causes of neuritis. This study examined antioxidative activities of methanol extracts of six amphibian species known to be medicinal animals (Rana catesbeiana, R. coreana, R. rugosa, R. dybowskii, R. nigromaculata, and Hyla japonica) and investigated their effects of inhibiting nitric oxide (NO) production and cytotoxicity on the murine macrophage RAW264.7 cells. As inflammation is closely associated with reactive oxygen species,assays on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, xanthine oxidase inhibitory activity, superoxide anion radical scavenging activity and NO scavenging activity of the extracts of the six species were performed to investigate their antioxidative activity. The results obtained were as follows; All extracts showed antioxidative activity, and the activity of R. dybowskii was the highest in comparison among those. Anti-inflammatory effects of the extracts were also examined, the five extracts except that of R. rugosa did not show cytotoxicity for RAW264.7 cells at the maximal concentration (1,000 μg mL-1). Selectivity index, meaning NO scavenging activity compared to cytotoxicity, showed the highest level in the extract of R. dybowskii. These results will be very useful basic data for future studies on prevention and treatment of human diseases to understand the biological roles of amphibian extracts throughout the antioxidative or anti-inflammatory pathways.
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참고문헌 (25)
참고문헌 신청
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Blois MS. / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181 : 1198 ~ 1200
Cheng ZJ. / 1998 / Antioxidant properties of butein isolated from Dalbergia odorifera / Biochem. Biophys. Acta 1392 : 291 ~ 299
Cho JH. / 2009 / Buforins : Histone H2Aderived antimicrobial peptides from toad stomach / Biochim. Biophys. Acta-Biomembr 1788 : 1564 ~ 1569
Deby C. / 1988 / Metabolism of polyunsaturated fatty acids, precursors of eicosanoids, In Prostaglandins: Biology and chemistry of prostaglandins and related eicosanoids / Churchill Livi
Blois MS. / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181 : 1198 ~ 1200
Cheng ZJ. / 1998 / Antioxidant properties of butein isolated from Dalbergia odorifera / Biochem. Biophys. Acta 1392 : 291 ~ 299
Cho JH. / 2009 / Buforins : Histone H2Aderived antimicrobial peptides from toad stomach / Biochim. Biophys. Acta-Biomembr 1788 : 1564 ~ 1569
Deby C. / 1988 / Metabolism of polyunsaturated fatty acids, precursors of eicosanoids, In Prostaglandins: Biology and chemistry of prostaglandins and related eicosanoids / Churchill Livi
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