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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Phytoestrogens display estrogen-like activity because of their structural
similarity to human estrogens and exhibit high affinity binding for the estrogen
receptors (ERs). The prevalence of phytoestrogens in our diets and the biological
effects that they may cause need to be fully examined. ER is the ancestral receptor
from which all other steroid receptors have evolved. Although phytoestrogens serve
specific signaling functions between the plants and insects, fungi, and bacteria, many
chemical signals are often misinterpreted as estrogenic signals in non- target
organisms such as vertebrates. There are no ERs in plants or in their most common
partners, insects. However, Rhizobium soil bacteria have NodD proteins which is an
intended target of phytoestrogen signaling and share genetic homology with the ER.
These two evolutionarily distant receptors both recognize and respond to a shared
group of chemical signals and ligands, including both agonists and antagonists. This
review briefly summarizes estrogen and estrogen receptors, kinds of important
phytoestrogens, their health effects as well as some of the evolutionary aspects of
mechanism by which phytoestrogen mimics the endogenous ER signaling in our body.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ / Gyorgypal Z and A Kondorosi. 1991. Homology of theligand-binding regions of Rhizobium symbiotic regulatoryprotein NodD and vertebrate nuclear receptors.Mol. Gen. Genet.
Altavilla D / 2004 / A Bitto and F Squadrito. . Cardiovasculareffects of the phytoestrogen genistein. Curr.Med. Chem. Cardiovasc. Hematol. Agents 2 2 : 179 ~ 186
Bennetts HW / / EJ Underwood and FL Shier. 1946. A specificbreeding problem of sheep on subterranean cloverpastures in Western Australia. Aust. Vet. J. 22 22 : 2 ~ 12
Bianchini F / 2003 / Wine and resveratrol :mechanisms of cancer prevention? 12 : 417 ~ 425
Bowers JL / 2000 / SC Jernigan and CM Klinge.. Resveratrol acts as a mixed agonist/antagonistfor estrogen receptors alpha and beta. Endocrinology141 141 : 3657 ~ 3667
Altavilla D / 2004 / A Bitto and F Squadrito. . Cardiovasculareffects of the phytoestrogen genistein. Curr.Med. Chem. Cardiovasc. Hematol. Agents 2 2 : 179 ~ 186
Bennetts HW / / EJ Underwood and FL Shier. 1946. A specificbreeding problem of sheep on subterranean cloverpastures in Western Australia. Aust. Vet. J. 22 22 : 2 ~ 12
Bianchini F / 2003 / Wine and resveratrol :mechanisms of cancer prevention? 12 : 417 ~ 425
Bowers JL / 2000 / SC Jernigan and CM Klinge.. Resveratrol acts as a mixed agonist/antagonistfor estrogen receptors alpha and beta. Endocrinology141 141 : 3657 ~ 3667
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