지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 514 - 519 (6page)
이용수
초록· 키워드
오류제보하기
Osteoclasts are multinucleated giant cells derived from myeloid progenitors. Excessive bone resorption by osteoclasts can result in serious clinical outcomes for which better treatment options are needed. Here, we identified fibronectin leucine-rich transmembrane protein 2 (Flrt2), a ligand of the Unc5 receptor family for neurons, as a novel target associated with the late/maturation stage of osteoclast differentiation. Flrt2 expression is induced by stimulation with receptor activator of nuclear factor-kB ligand (RANKL). Flrt2 deficiency in osteoclasts results in reduced hyper-multinucleation, which could be restored by RNAi-mediated knockdown of Unc5b. Treatment with Netrin1, another ligand of Unc5b which negatively controls osteoclast multinucleation through down regulation of RANKL-induced Rac1 activation, showed no inhibitory effects on Flrt2-deficient cells. In addition, RANKLinduced Rac1 activation was attenuated in Flrt2-deficient cells. Taken together, these results suggest that Flrt2 regulates osteoclast multinucleation by interfering with Netrin 1-Unc5b interaction and may be a suitable therapeutic target for diseases associated with bone remodeling.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Teitelbaum SL / 2003 / Genetic regulation of osteoclast development and function / Nat Rev Genet 4:638~649
Walsh MC / 2006 / Osteoimmunology : interplay between the immune system and bone metabolism / Annu Rev Immunol 24:33~63
Nakashima T / 2011 / Evidence for osteocyte regulation of bone homeostasis through RANKL expression / Nat Med 17:1231~1234
Xiong J / 2011 / Matrix-embedded cells control osteoclast formation / Nat Med 17:1235~1241
Moutsopoulos NM / 2014 / Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss / Sci Transl Med 6:229~240
Walsh MC / 2006 / Osteoimmunology : interplay between the immune system and bone metabolism / Annu Rev Immunol 24:33~63
Nakashima T / 2011 / Evidence for osteocyte regulation of bone homeostasis through RANKL expression / Nat Med 17:1231~1234
Xiong J / 2011 / Matrix-embedded cells control osteoclast formation / Nat Med 17:1235~1241
Moutsopoulos NM / 2014 / Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss / Sci Transl Med 6:229~240
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases
Experimental and Molecular Medicine
2024 .02
-
Adipose Tissue-Derived Mesenchymal Stem Cell Inhibits Osteoclast Differentiation through Tumor Necrosis Factor Stimulated Gene-6
조직공학과 재생의학
2024 .06
-
Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
BMB Reports
2018 .01
-
Tusc2/Fus1 regulates osteoclast differentiation through NF-kB and NFATc1
BMB Reports
2017 .01
-
Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways
BMB Reports
2017 .01
-
Remifentanil Negatively Regulates RANKL-Induced Osteoclast Differentiation and Bone Resorption by Inhibiting c-Fos/NFATc1 Expression
조직공학과 재생의학
2018 .01
-
SU-8 Inhibit Osteoclast Differentiation by downregulating NFATc1
한국생물공학회 학술대회
2017 .10
-
RACK1 interaction with c-Src is essential for osteoclast function
Experimental and Molecular Medicine
2019 .01
-
Purification of Receptor activator of nuclear factor-kappa B ligand using E. coli fed batch fermentation
한국생물공학회 학술대회
2015 .04
-
Serum amyloid A inhibits RANKL-induced osteoclast formation
Experimental and Molecular Medicine
2015 .01
-
Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility
BMB Reports
2018 .01
-
PyP-R13-6 Inhibits Osteoclast Differentiation In vitro and In vivo
한국생물공학회 학술대회
2017 .04
-
Spi-C positively regulates RANKL-mediated osteoclast differentiation and function
Experimental and Molecular Medicine
2020 .01
-
2-O-digalloyl-1,3,4,6-tetra-O-galloyl--D-glucose isolated from Galla Rhois suppresses osteoclast differentiation and function by inhibiting NF-B signaling
BMB Reports
2019 .01
-
Pentamidine Inhibits Titanium Particle-Induced Osteolysis In Vivo and Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation In Vitro
조직공학과 재생의학
2019 .01
-
Inhibitory effects of acid extracts from Gracilaria verrucosa on osteoclast differentiation in vitro
한국생물공학회 학술대회
2016 .10
-
The estrogen-related receptor γ modulator, GSK5182, inhibits osteoclast differentiation and accelerates osteoclast apoptosis
BMB Reports
2021 .01
-
IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
BMB Reports
2021 .09
-
Savinin Suppresses Osteoclast Formation via Down-regulating NFATc1
한국생물공학회 학술대회
2017 .04
-
Treatment of mutant RANKL on RANKL-induced mice for osteoporosis
한국생물공학회 학술대회
2018 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0