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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 232 - 241 (10page)
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초록· 키워드
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Objective The objective of this study was to analyze uptake patterns and intensity of 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) radioligands in carotid atheroma among stroke patients according to carotid atheroma characteristics. Methods Between September 2015 and January 2017, consecutive acute stroke or transient ischemic attack patients with 50% or more proximal internal carotid artery stenosis on brain computed tomography angiography were prospectively enrolled. All patients received FDG and NaF positron emission tomography (PET) evaluation when their neurological status was stabilized. Uptake values of FDG and NaF were compared by target to blood ratio (TBR) according to the calcification burden, atheroma volume and the presence of a necrotic core of carotid atheroma. Results A total of 18 patients with 36 carotid arteries were finally enrolled, with 10 patients diagnosed as acute cerebral infarction due to symptomatic carotid stenosis. FDG uptake at symptomatic carotid arteries was significantly more increased than that at asymptomatic arteries (TBR: 1.17±0.23 vs. 1.01±0.15, Mann-Whitney U-test, p=0.02), but NaF uptake was not different (TBR: 1.38±0.49 vs. 1.51±0.40, p=0.40). In terms of calcification degree, NaF uptake increased as calcification burden increased (none, 1.28±0.36; spotty, 1.29±0.29; linear, 1.74±0.44; analysis of variance, p=0.02). Conclusion Carotid evaluation by FDG is superior to NaF PET in the detection of symptomatic carotid atherosclerosis among stroke patients. NaF PET uptake reflects the overall calcification burden.
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참고문헌 (12)
참고문헌 신청
O'Donnell MJ / 2016 / Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a casecontrol study / Lancet 388:761~775
Abbott AL / 2015 / Systematic review of guidelines for the management of asymptomatic and symptomatic carotid stenosis / Stroke 46:3288~3301
Tarkin JM / 2016 / Imaging atherosclerosis / Circ Res 118:750~769
Joseph P / 2016 / Imaging atherosclerosis with positron emission tomography / Eur Heart J 37:2974~2980
Tarkin JM / 2014 / PET imaging of inflammation in atherosclerosis / Nat Rev Cardiol 11:443~457
Abbott AL / 2015 / Systematic review of guidelines for the management of asymptomatic and symptomatic carotid stenosis / Stroke 46:3288~3301
Tarkin JM / 2016 / Imaging atherosclerosis / Circ Res 118:750~769
Joseph P / 2016 / Imaging atherosclerosis with positron emission tomography / Eur Heart J 37:2974~2980
Tarkin JM / 2014 / PET imaging of inflammation in atherosclerosis / Nat Rev Cardiol 11:443~457
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