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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 86 - 108 (23page)
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In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.
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참고문헌 (270)
참고문헌 신청
Benayoun BA / 2015 / Epigenetic regulation of ageing : linking environmental inputs to genomic stability / Nat Rev Mol Cell Biol 16:593~610
Booth LN / 2016 / The Aging Epigenome / Mol Cell 62:728~744
Pal S / 2016 / Epigenetics and aging / Sci Adv 2:e1600584
Sen P / 2016 / Epigenetic Mechanisms of Longevity and Aging / Cell 166:822~839
Kennedy BK / 2014 / Geroscience : linking aging to chronic disease / Cell 159:709~713
Booth LN / 2016 / The Aging Epigenome / Mol Cell 62:728~744
Pal S / 2016 / Epigenetics and aging / Sci Adv 2:e1600584
Sen P / 2016 / Epigenetic Mechanisms of Longevity and Aging / Cell 166:822~839
Kennedy BK / 2014 / Geroscience : linking aging to chronic disease / Cell 159:709~713
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