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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 70 - 85 (16page)
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Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.
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참고문헌 (112)
참고문헌 신청
Barbieri M / 2003 / Insulin/IGF-I-signaling pathway : an evolutionarily conserved mechanism of longevity from yeast to humans / Am J Physiol Endocrinol Metab 285:E1064~E1071
Fontana L / 2010 / Extending healthy life span--from yeast to humans / Science 328:321~326
Hwangbo DS / 2004 / Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body / Nature 429:562~566
Holzenberger M / 2003 / IGF-1receptor regulates lifespan and resistance to oxidative stress in mice / Nature 421:182~187
Bonafe M / 2009 / Genetic polymorphism in long-lived people : cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity / Mol Cell Endocrinol 299:118~123
Fontana L / 2010 / Extending healthy life span--from yeast to humans / Science 328:321~326
Hwangbo DS / 2004 / Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body / Nature 429:562~566
Holzenberger M / 2003 / IGF-1receptor regulates lifespan and resistance to oxidative stress in mice / Nature 421:182~187
Bonafe M / 2009 / Genetic polymorphism in long-lived people : cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity / Mol Cell Endocrinol 299:118~123
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