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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 64 - 69 (6page)
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The loss of skeletal muscle, called sarcopenia, is an inevitable event during the aging process, and significantly impacts quality of life. Autophagy is known to reduce muscle atrophy caused by dysfunctional organelles, even though the molecular mechanism remains unclear. Here, we have discuss the current understanding of exercise-induced autophagy activation in skeletal muscle regeneration and remodeling, leading to sarcopenia intervention. With aging, dysregulation of autophagy flux inhibits lysosomal storage processes involved in muscle biogenesis. AMPK-ULK1 and the FoxO/PGC-1ɑ signaling pathways play a critical role in the induction of autophagy machinery in skeletal muscle, thus these pathways could be targets for therapeutics development. Autophagy has been also shown to be a critical regulator of stem cell fate, which determines satellite cell differentiation into muscle fiber, thereby increasing muscle mass. This review aims to provide a comprehensive understanding of the physiological role of autophagy in skeletal muscle aging and sarcopenia.
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참고문헌 (54)
참고문헌 신청
Masiero E / 2009 / Autophagy is required to maintain muscle mass / Cell metab 10:507~515
박성섭 / 2017 / Molecular mechanisms and therapeutic interventions in sarcopenia / Osteoporosis and Sarcopenia 3(3):117~122
Kwak JY / 2018 / Prediction of sarcopenia using a combination of multiple serum biomarkers / Sci Rep 8:8574
Mordier S / 2000 / Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway / J Biol Chem 275:29900~29906
Mizushima N / 2004 / In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker / Mol Biol Cell 15:1101~1111
박성섭 / 2017 / Molecular mechanisms and therapeutic interventions in sarcopenia / Osteoporosis and Sarcopenia 3(3):117~122
Kwak JY / 2018 / Prediction of sarcopenia using a combination of multiple serum biomarkers / Sci Rep 8:8574
Mordier S / 2000 / Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway / J Biol Chem 275:29900~29906
Mizushima N / 2004 / In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker / Mol Biol Cell 15:1101~1111
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