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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 126 - 132 (7page)
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Background: The current Surviving Sepsis Campaign guidelines recommend the remeasure ment of lactate levels if the initial lactate level is elevated; however, the prognostic value of lactate kinetics is limited and inconsistent. We attempted to determine the efficacy of the lactate area score (calculated from repeated lactate measurements during initial resuscitation) as a prognostic marker of septic shock in the emergency department (ED). Methods: We performed a retrospective study of adult patients with septic shock in the ED of a single tertiary medical center. Serial lactate levels were measured five times within 12 hours. We also compared the initial lactate level, maximum lactate level, and lactate area score. The lactate area score was defined as the sum of the area under the curve measured at 2, 4, 6, and 12 hours following the initial measurement. Results: A total of 362 patients were enrolled in this study, and the overall 28-day mortality was 31.8%. The lactate area score of serial lactate levels as well as the initial (median [inter quartile range], 4.9 [3.4 to 10.5]; P =0.003) and maximum (7.3 [4.2 to 13.2]; P<0.001) lactate levels were significantly higher in the non-survivor group. However, in multivariate analysis, only the lactate area score (odds ratio, 1.013; 95% confidence interval, 1.007 to 1.019) was significantly associated with 28-day mortality. Conclusions: The early lactate area score may be a possible prognostic marker for predicting the 28-day mortality of adult septic shock patients. Further prospective interventional studies should be conducted to validate our results.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Shankar-Hari M / 2016 / Developing a new definition and assessing new clinical criteria for septic shock : for the third international consensus definitions for Sepsis and Septic Shock(Sepsis-3) / JAMA 315:775~787
Levy MM / 2018 / The surviving sepsis campaign bundle : 2018 update / Crit Care Med 46:997~1000
Jansen TC / 2009 / Blood lactate monitoring in critically ill patients : a systematic health technology assessment / Crit Care Med 37:2827~2839
Jansen TC / 2008 / The prognostic value of blood lactate levels relative to that of vital signs in the pre-hospital setting : a pilot study / Crit Care 12:R160
Jansen TC / 2009 / Association between blood lactate levels, Sequential Organ Failure Assessment subscores, and 28-day mortality during early and late intensive care unit stay : a retrospective observational study / Crit Care Med 37:2369~2374
Levy MM / 2018 / The surviving sepsis campaign bundle : 2018 update / Crit Care Med 46:997~1000
Jansen TC / 2009 / Blood lactate monitoring in critically ill patients : a systematic health technology assessment / Crit Care Med 37:2827~2839
Jansen TC / 2008 / The prognostic value of blood lactate levels relative to that of vital signs in the pre-hospital setting : a pilot study / Crit Care 12:R160
Jansen TC / 2009 / Association between blood lactate levels, Sequential Organ Failure Assessment subscores, and 28-day mortality during early and late intensive care unit stay : a retrospective observational study / Crit Care Med 37:2369~2374
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