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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 258 - 266 (9page)
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초록· 키워드
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Objective Fatty liver is associated with insulin resistance-related diseases, such as dyslipidemia, obesity, and type 2 diabetes. The aim of this study was to evaluate the association of dyslipidemia with fatty liver and assess the differences in these associations according to the degree of hepatic steatosis. Methods A total of 2,462 subjects (1,679 men and 783 women) who underwent a comprehensive health check-up (including abdominal computed tomography) from January 2010 to December 2013 were enrolled at Samsung Changwon Hospital Healthcare Center. The liver attenuation index (LAI), defined as the difference between mean hepatic and splenic attenuation, was used to assess the degree of hepatic steatosis. An LAI below 5 Hounsfield units was defined as fatty liver. Results We found that 32.2% of the study subjects had fatty liver. Serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG), and fasting blood glucose concentrations and glycated hemoglobin (HbA1c percentage) were significant greater in the fatty liver group compared with the non-fatty liver group, while serum high-density lipoprotein cholesterol (HDL-C) was significantly lower in the fatty liver group. Subjects with fatty liver had 1.7-fold greater risk of dyslipidemia than those without fatty liver after adjusting for age, sex, body mass index (BMI), and HbA1c. When individuals with fatty liver were analyzed by tertiles of LAI values, LDL-C, TG, fasting glucose, BMI, and HbA1c concentrations increased while HDL-C decreased with decreasing LAI tertiles. Compared with LAI tertile 3, the risk for dyslipidemia significantly increased with adjusted odds ratios of 1.42, and 1.81 in tertiles 2 and 1, respectively. Conclusion Fatty liver was significantly associated with dyslipidemia and this association varied according to the degree of hepatic steatosis.
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참고문헌 (22)
참고문헌 신청
Mashek DG / 2015 / Hepatic lipid droplet biology: getting to the root of fatty liver / Hepatology 62:964~967
Katsiki N / 2016 / Non-alcoholic fatty liver disease and dyslipidemia: an update / Metabolism 65:1109~1123
Bae JC / 2010 / Impact of nonalcoholic fatty liver disease on insulin resistance in relation to HbA1c levels in nondiabetic subjects / Am J Gastroenterol 105:2389~2395
Limanond P / 2004 / Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings / Radiology 230:276~280
Kodama Y / 2007 / Comparison of CT methods for determining the fat content of the liver / AJR Am J Roentgenol 188:1307~1312
Katsiki N / 2016 / Non-alcoholic fatty liver disease and dyslipidemia: an update / Metabolism 65:1109~1123
Bae JC / 2010 / Impact of nonalcoholic fatty liver disease on insulin resistance in relation to HbA1c levels in nondiabetic subjects / Am J Gastroenterol 105:2389~2395
Limanond P / 2004 / Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings / Radiology 230:276~280
Kodama Y / 2007 / Comparison of CT methods for determining the fat content of the liver / AJR Am J Roentgenol 188:1307~1312
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