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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제1호
- 발행연도
- 2019.1
- 수록면
- 9 - 15 (7page)
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초록· 키워드
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Intra-articular (IA) administration of therapeutic agents has been employed to selectively deliver active compounds at their site of action for the treatment of chronic joint diseases such as osteoarthritis, rheumatoid arthritis, and joint pain. Direct IA delivery of active compounds to local tissues occasionally provides improved therapeutic outcomes with reduced dose, while minimizing systemic exposure and undesirable adverse effects. However, many small drugs (< 10,000 Da) administered intra-articularly, tend to be rapidly effluxed from the synovium into the blood stream, thus requiring frequent IA injection. To date, different pharmaceutical approaches have been investigated, including polymer and/or lipid-based nanoparticles (NPs), microparticles (MPs), conventional and/or thermo-responsive hydrogels, drug suspension, and oily depot systems, to prolong the drug retention time in the joint, thus improving the pharmacokinetic profile and/or the therapeutic efficacy of active compounds. Herein, we have summarized the recent research trends on IA delivery systems with a focus on NPs, MPs, and hydrogel system, which have been studied most extensively to achieve extended retention time following IA injection.
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참고문헌 (43)
참고문헌 신청
Abd-Allah H / 2016 / Injectable long acting chitosan/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam : optimization and in vivo evaluation / Carbohydr Polym 149:263~273
Ayral X / 2001 / Injections in the treatment of osteoarthritis / Best Pract Res Clin Rheumatol 15:609~626
Betre H / 2006 / A thermally responsive biopolymer for intra-articular drug delivery / J Control Release 115:175~182
Bodick N / 2015 / An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee : a randomized clinical trial / J Bone Joint Surg Am 97:877~888
Bonanomi MH / 1987 / Studies of pharmacokinetics and therapeutic effects of glucocorticoids entrapped in liposomes after intraarticular application in healthy rabbits and in rabbits with antigen-induced arthritis / Rheumatol Int 7:203~212
Ayral X / 2001 / Injections in the treatment of osteoarthritis / Best Pract Res Clin Rheumatol 15:609~626
Betre H / 2006 / A thermally responsive biopolymer for intra-articular drug delivery / J Control Release 115:175~182
Bodick N / 2015 / An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee : a randomized clinical trial / J Bone Joint Surg Am 97:877~888
Bonanomi MH / 1987 / Studies of pharmacokinetics and therapeutic effects of glucocorticoids entrapped in liposomes after intraarticular application in healthy rabbits and in rabbits with antigen-induced arthritis / Rheumatol Int 7:203~212
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