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논문 기본 정보
- 자료유형
- 학술저널
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- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제1호
- 발행연도
- 2019.1
- 수록면
- 27 - 36 (10page)
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초록· 키워드
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Vesicular carriers (VCs) offer enhanced and sustained delivery of drugs. The aim of this study was to explore the effects of ethanol concentration in VCs on topical delivery of a poorly water-soluble drug, using griseofulvin as prototype. VCs containing varying quantities of ethanol were prepared by solvent evaporation using Phospholipon ® 90H (P90H) and characterized for entrapment efficiency (EE), morphology, size and size distribution, stability, viscosity and skin retention. Permeation profiles were assessed using rat skin and Franz diffusion cell and withdrawn samples analyzed spectrophotometrically. Spherical vesicles of average size of 137.70 ± 51.62 nm and polydipersity index of 0.555 were produced. Vesicle sizes decreased with increase in ethanol concentration. EE of 68.0 ± 5.6% was obtained for the optimized formulation. Differential scanning calorimetry indicated reversible perturbation of the skin layers as the mechanism of permeation. Permeation generally increased with increase in ethanol concentration. Ethosomal nanovesicular carriers encapsulating griseofulvin were formulated, which showed potentials for sustained and enhanced delivery through rat skin in direct proportion with ethanol concentration.
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참고문헌 (42)
참고문헌 신청
Agubata CO / 2015 / Formulation, characterization and anti-malarial activity of homolipid-based artemether microparticles / Int J Pharm 478:202~222
Attama AA / 2008 / Diclofenac sodium delivery to the eye : in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct / Int J Pharm 355:307~313
Attama AA / 2009 / Sustained release and permeation of timolol from surface-modified solid-lipid nanoparticles through bioengineered human cornea / Curr Eye Res 34:698~705
Aulton ME / 1999 / Pharmaceutics: the science of dosage form design / Churchill Livingstone
Barry BW / 2001 / Novel mechanisms and devices to enable successful transdermal drug delivery / Eur J Pharm Sci 14(2):101~114
Attama AA / 2008 / Diclofenac sodium delivery to the eye : in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct / Int J Pharm 355:307~313
Attama AA / 2009 / Sustained release and permeation of timolol from surface-modified solid-lipid nanoparticles through bioengineered human cornea / Curr Eye Res 34:698~705
Aulton ME / 1999 / Pharmaceutics: the science of dosage form design / Churchill Livingstone
Barry BW / 2001 / Novel mechanisms and devices to enable successful transdermal drug delivery / Eur J Pharm Sci 14(2):101~114
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