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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제5호
- 발행연도
- 2019.1
- 수록면
- 827 - 837 (11page)
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초록· 키워드
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The present study was conducted with the aim to investigate the ameliorative effects of a new soybean product (cheonggukjang) fermented with Bacillus amyloliquefaciens SCGB1 (SFBA) in atopic dermatitis (AD) mouse model. Visual evaluation of AD induction in the mice indicated the remarkable control of SFBA in reducing the pathological severity of AD-like skin lesions reported as the SCORAD score of AD clinical symptoms. The results revealed that SFBA reduced dorsal skin and epidermal thickness to a similar extent with prednisolone. Further analysis revealed the dominance of SFBA in restraining mast cell infiltration in the dermis; immunoglobulin-E expression in serum; and TH2 IL-4 cytokine and itch-related IL-31 cytokine in the mice skin and serum. SFBA also suppressed scratching behaviours in mice induced by compound 48/80. Further histological findings also revealed the alleviation of collagen fiber deposition in dermal skin of the AD mice model. These actions of SFBA were examined to be mediated by its suppression of the phosphorylation activation of key signalling molecules such as NF-κB and MAPK responsible for the induction of cytokine production. Thus, SFBA can be considered as a promising functional food for managing clinical, histological and immunological spectra associated with AD.
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참고문헌 (30)
참고문헌 신청
Brandt E B / 2011 / Th2 cytokines a nd a topic dermatitis / J. Clin. Cell. Immunol 2:pii:110
Odhiambo JA / 2009 / Global variations in prevalence of eczema symptoms in children from ISAAC phase three / J. Allergy Clin. Immunol 124:1251~1258
Novak N / 2012 / An update on the role of human dendritic cells in patients with atopic dermatitis / J. Allergy Clin. Immunol 129:879~886
Ferretti E / 2017 / The IL-31/IL-31receptor axis : general features and role in tumor microenvironment / J. Leukoc. Biol 102:711~717
Howell MD / 2009 / Cytokine modulation of atopic dermatitis filaggrin skin expression / J. Allergy Clin. Immunol 124:R7~R12
Odhiambo JA / 2009 / Global variations in prevalence of eczema symptoms in children from ISAAC phase three / J. Allergy Clin. Immunol 124:1251~1258
Novak N / 2012 / An update on the role of human dendritic cells in patients with atopic dermatitis / J. Allergy Clin. Immunol 129:879~886
Ferretti E / 2017 / The IL-31/IL-31receptor axis : general features and role in tumor microenvironment / J. Leukoc. Biol 102:711~717
Howell MD / 2009 / Cytokine modulation of atopic dermatitis filaggrin skin expression / J. Allergy Clin. Immunol 124:R7~R12
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