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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제1호
- 발행연도
- 2019.1
- 수록면
- 21 - 29 (9page)
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The effects of Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts were determined, and the conversion of its components was also analyzed. Fermentation was performed at varying L. angustifolia extract and MRS medium concentrations, and optimal fermentation conditions were selected. L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1 expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented extract. This was observed even at fermented extract concentrations lower than those of non-fermented extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less reduction in collagen production upon UVB irradiation than those treated with non-fermented extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50% higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin and apigenin glycosides of L. angustifolia were converted during fermentation, and identified using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract on MMP-1 expression and collagen decrease in UVB-irradiated human skin fibroblasts were increased through fermentation by P. pentosaceus.
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참고문헌 (38)
참고문헌 신청
MacNeil S / 2007 / Progress and opportunities for tissueengineered skin / Nature 445:874~880
Hussain SH / 2013 / The biomechanical properties of the skin / Dermatol. Surg 39:193~203
D’Orazio J / 2013 / UV radiation and the skin / Int. J. Mol. Sci 14:12222~12248
Rittie L / 2002 / UV-light-induced signal cascades and skin aging / Ageing Res. Rev 1:705~720
Ramachandran S / 2008 / Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes / Chem. Biol. Interact 176:99~107
Hussain SH / 2013 / The biomechanical properties of the skin / Dermatol. Surg 39:193~203
D’Orazio J / 2013 / UV radiation and the skin / Int. J. Mol. Sci 14:12222~12248
Rittie L / 2002 / UV-light-induced signal cascades and skin aging / Ageing Res. Rev 1:705~720
Ramachandran S / 2008 / Effect of ursolic acid, a triterpenoid antioxidant, on ultraviolet-B radiation-induced cytotoxicity, lipid peroxidation and DNA damage in human lymphocytes / Chem. Biol. Interact 176:99~107
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