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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 403 - 405 (3page)
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Dear Editor, The SET-NUP214 fusion gene has been observed most commonly in T-cell ALL (T-ALL) patients, with a frequency of about 3.3% to 10.3%, and in acute undifferentiated leukemia (AUL) patients, but is rare in AML patients [1-4]. Most patients diagnosed as having T-ALL have normal karyotypes according to conventional cytogenetic analysis [2]. SET-NUP214 fusion, though reported rarely, has a significant value in acute leukemia because it often predicts poor patient outcomes [1]. We report a rare case of AML with SET-NUP214 fusion and massive hyperdiploidy. To the best of our knowledge, this is the first case of AML with SET-NUP214 fusion in Korea. This study was approved by the Institutional Review Board of Dong-A University Hospital, Busan, Korea, and informed consent was obtained from the patient.
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참고문헌 (10)
참고문헌 신청
Zhu HH / 2016 / B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement : a case report and review of the literature / Oncol Lett 11:2644~2650
Lee SG / 2011 / T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement : a case study and review of the literature / Ann Clin Lab Sci 41:267~272
Chae H / 2012 / Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34); SET-NUP214 rearrangement / Ann Hematol 91:193~201
Ozbek U / 2007 / SET-CAN, the product of the t(9;9)in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice / American J Pathol 171:654~666
Kim J / 2010 / Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia / Cancer Genet Cytogenet 201:73~80
Lee SG / 2011 / T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement : a case study and review of the literature / Ann Clin Lab Sci 41:267~272
Chae H / 2012 / Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34); SET-NUP214 rearrangement / Ann Hematol 91:193~201
Ozbek U / 2007 / SET-CAN, the product of the t(9;9)in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice / American J Pathol 171:654~666
Kim J / 2010 / Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia / Cancer Genet Cytogenet 201:73~80
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