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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 228 - 236 (9page)
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CD4 T cells differentiate into RORγt/IL-17A-expressing cells in the small intestine following colonization by segmented filamentous bacteria (SFB). However, it remains unclear whether SFB-specific CD4 T cells can differentiate directly from na?ve precursors, and whether their effector differentiation is solely directed towards the Th17 lineage. In this study, we used adoptive T cell transfer experiments and showed that na?ve CD4 T cells can migrate to the small intestinal lamina propria (sLP) and differentiate into effector T cells that synthesize IL-17A in response to SFB colonization. Using single cell RT-PCR analysis, we showed that the progenies of SFB responding T cells are not uniform but composed of transcriptionally divergent populations including Th1, Th17 and follicular helper T cells. We further confirmed this finding using in vitro culture of SFB specific intestinal CD4 T cells in the presence of cognate antigens, which also generated heterogeneous population with similar features. Collectively, these findings indicate that a single species of intestinal bacteria can generate a divergent population of antigen-specific effector CD4 T cells, rather than it provides a cytokine milieu for the development of a particular effector T cell subset.
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참고문헌 (33)
참고문헌 신청
Atarashi, K. / 2015 / Th17 cell induction by adhesion of microbes to intestinal epithelial cells / Cell 163:367~380
Atarashi, K. / 2011 / Induction of colonic regulatory T cells by indigenous Clostridium species / Science 331:337~341
Aujla, S. J. / 2007 / Th17 cells and mucosal host defense / Semin Immunol 19:377~382
Basdeo, S. A. / 2017 / Ex-Th17(nonclassical Th1)cells are functionally distinct from classical Th1 and Th17 cells and are not constrained by regulatory T cells / J. Immunol 198:2249~2259
Benson, A. / 2009 / Gut commensal bacteria direct a protective immune response against Toxoplasma gondii / Cell Host Microbe 6:187~196
Atarashi, K. / 2011 / Induction of colonic regulatory T cells by indigenous Clostridium species / Science 331:337~341
Aujla, S. J. / 2007 / Th17 cells and mucosal host defense / Semin Immunol 19:377~382
Basdeo, S. A. / 2017 / Ex-Th17(nonclassical Th1)cells are functionally distinct from classical Th1 and Th17 cells and are not constrained by regulatory T cells / J. Immunol 198:2249~2259
Benson, A. / 2009 / Gut commensal bacteria direct a protective immune response against Toxoplasma gondii / Cell Host Microbe 6:187~196
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