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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제8호
- 발행연도
- 2019.1
- 수록면
- 1,299 - 1,309 (11page)
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초록· 키워드
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As an opportunistic bacterial pathogen, Pseudomonas aeruginosa PAO1 contains two phenazineproducing gene operons, phzA1B1C1D1E1F1G1 (phz1) and phzA2B2C2D2E2F2G2 (phz2), each of which is independently capable of encoding all enzymes for biosynthesizing phenazines, including phenazine-1-carboxylic acid and its derivatives. Other previous study reported that the RpoS-deficient mutant SS24 overproduced pyocyanin, a derivative of phenazine-1- carboxylic acid. However, it is not known how RpoS mediates the expression of two phz operons and regulates pyocyanin biosynthesis in detail. In this study, with deletion of the rpoS gene in the PAΔphz1 mutant and the PAΔphz2 mutant respectively, we demonstrated that RpoS exerted opposite regulatory roles on the expression of the phz1and phz2 operons. We also confirmed that the phz1 operon played a critical role and especially biosynthesized much more phenazines than the phz2 operon when the rpoS gene was knocked out in P. aeruginosa. By constructing the translational reporter fusion vector lasR’-’lacZ and the chromosomal fusion mutant PAΔlasR::lacZ, we verified that RpoS deficiency caused increased expression of lasR, a transcription regulator gene in a first quorum sensing system (las) that activates overexpression of the phz1 operon, suggesting that in the absence of RpoS, LasR might act as an intermediate in overproduction of phenazine biosynthesis mediated by the phz1 operon in P. aeruginosa.
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참고문헌 (47)
참고문헌 신청
Chugani S / 2010 / LuxR homolog-independent gene regulation by acyl-homoserine lactones in Pseudomonas aeruginosa / Proc. Natl. Acad. Sci. USA 107:10673~10678
Crousilles A / 2015 / Which microbial factors really are important in Pseudomonas aeruginosa infections? / Future Microbiol 10:1825~1836
Limmer S / 2011 / Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model / Proc. Natl. Acad. Sci. USA 108:17378~17383
Liu J / 2013 / Components of the cultivated red seaweed Chondrus crispus enhance the immune response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 pathways / Appl. Environ. Microbiol 79:7343~7350
Raneri M / 2018 / Pseudomonas aeruginosa mutants defective in glucose uptake have pleiotropic phenotype and altered virulence in non-mammal infection models / Sci. Rep 8:16912
Crousilles A / 2015 / Which microbial factors really are important in Pseudomonas aeruginosa infections? / Future Microbiol 10:1825~1836
Limmer S / 2011 / Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model / Proc. Natl. Acad. Sci. USA 108:17378~17383
Liu J / 2013 / Components of the cultivated red seaweed Chondrus crispus enhance the immune response of Caenorhabditis elegans to Pseudomonas aeruginosa through the pmk-1, daf-2/daf-16, and skn-1 pathways / Appl. Environ. Microbiol 79:7343~7350
Raneri M / 2018 / Pseudomonas aeruginosa mutants defective in glucose uptake have pleiotropic phenotype and altered virulence in non-mammal infection models / Sci. Rep 8:16912
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