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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 365 - 371 (7page)
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Systemic sclerosis (SSc) is an autoimmune disorder characterized by the fibrosis of skin, heart, lung, and kidney as well. Excessive activation of fibroblasts is associated with higher expression of Notch1 and/or Notch3 genes. The constitutive expression of NOTCH genes was described in epithelial cells: epidermal keratinocytes, hair follicle cells and sebaceous glands. The NOTCH signalling pathway may be involved in the development of fibrosis, myofibroblast formation and the process of epithelial-mesenchymal transition. Activation of the NOTCH pathway leads to morphological, phenotypic and functional changes in epithelial cells. Furthermore, inhibition of Notch signalling prevent the development of fibrosis in different models, among them, bleomycin-induced fibrosis and in the Task-1 mause model. Molecular mechanisms, including the role of NOTCH signaling pathway, associated with fibrosis in SSc have not been completely recognized.
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등록된 정보가 없습니다.
참고문헌 (92)
참고문헌 신청
Wilson MD / 2015 / Fibrogenesis : mechanisms, dynamics and clinical implications / Iran J Pathol 10:83~88
Hernandez-Gea V / 2011 / Pathogenesis of liver fibrosis / Annu Rev Pathol 6:425~456
Pattanaik D / 2015 / Pathogenesis of systemic sclerosis / Front Immunol 6:272
Beyer C / 2012 / Innovative antifibrotic therapies in systemic sclerosis / Curr Opin Rheumatol 24:274~280
LeRoy EC / 1988 / Scleroderma(systemic sclerosis) : classification, subsets and pathogenesis / J Rheumatol 15:202~205
Hernandez-Gea V / 2011 / Pathogenesis of liver fibrosis / Annu Rev Pathol 6:425~456
Pattanaik D / 2015 / Pathogenesis of systemic sclerosis / Front Immunol 6:272
Beyer C / 2012 / Innovative antifibrotic therapies in systemic sclerosis / Curr Opin Rheumatol 24:274~280
LeRoy EC / 1988 / Scleroderma(systemic sclerosis) : classification, subsets and pathogenesis / J Rheumatol 15:202~205
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