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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 75 - 81 (7page)
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초록· 키워드
오류제보하기
Purpose: There are concerns that administration of bisphosphonate (BP) can substantially suppress bone turnover, potentially interfering with fracture healing. We investigated the effects of preoperative BP administration before internal fixation of intertrochanteric femoral fractures using fracture healing and clinical outcomes. Materials and Methods: We retrospectively analyzed data from 130 patients who underwent internal fixation for osteoporotic intertrochanteric femoral fractures between March 2012 and July 2016. Patients previously treated with BPs for at least 3 months (BP group; n=29) were compared with the remaining patients (BP-naïve group; n=101). Radiographs were used to assess and compare fracture healing 3 months and 1 year postsurgery. The primary clinical outcome measure assessed was change in Koval score. Results: Fracture union at 3 months after surgery was verified in 72.4% of patients (21/29) in the BP group and 90.1% of patients (91/101) in the BP-naïve group (P=0.027). Fracture union at 1 year postsurgery (BP group, 93.1% [27/29] vs. BP-naïve group, 97.0% [98/101], P=0.310) and change in Koval score (1.1 vs. 1.0, P=0.694) were not significantly different between the groups. Multivariable logistic regression analysis revealed that a history of BP administration was associated with an increased risk of delayed union at 3 months postsurgery (P=0.014). Conclusion: Preoperative administration of BP was associated with a decreased fracture healing rate 3 months after internal fixation, compared with BP-naïve patients. Therefore, patients previously treated with a BP should be carefully allowed to wean off walking aids and transition to full weight-bearing in the early postoperative period.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Ettinger B / 1999 / Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators / JAMA 282:637~645
Watts NB / 2010 / Long-term use of bisphosphonates in osteoporosis / J Clin Endocrinol Metab 95:1555~1565
Molvik H / 2015 / Bisphosphonates and their influence on fracture healing : a systematic review / Osteoporos Int 26:1251~1260
Murakami H / 1995 / A possible mechanism of the specific action of bisphosphonates on osteoclasts : tiludronate preferentially affects polarized osteoclasts having ruffled borders / Bone 17:137~144
Sato M / 1990 / Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy / J Bone Miner Res 5:31~40
Watts NB / 2010 / Long-term use of bisphosphonates in osteoporosis / J Clin Endocrinol Metab 95:1555~1565
Molvik H / 2015 / Bisphosphonates and their influence on fracture healing : a systematic review / Osteoporos Int 26:1251~1260
Murakami H / 1995 / A possible mechanism of the specific action of bisphosphonates on osteoclasts : tiludronate preferentially affects polarized osteoclasts having ruffled borders / Bone 17:137~144
Sato M / 1990 / Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy / J Bone Miner Res 5:31~40
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