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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제23권 제2호
- 발행연도
- 2019.1
- 수록면
- 125 - 135 (11page)
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초록· 키워드
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Purpose: The purpose of this study was to evaluate dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI), and diffusion-weighted imaging (DWI) variables, for axillary lymph node (ALN) metastasis in the early stage of breast cancer. Materials and Methods: January 2011-April 2015, 787 patients with early stage of breast cancer were retrospectively reviewed. Only cases of invasive ductal carcinoma, were included in the patient population. Among them, 240 patients who underwent 3.0- T DCE-MRI, including DWI with b value 0 and 800 s/mm2 were enrolled. MRI variables (adjacent vessel sign, whole-breast vascularity, initial enhancement pattern, quantitative kinetic parameters, signal enhancement ratio (SER), tumor apparent diffusion coefficient (ADC), peritumoral ADC, and peritumor-tumor ADC ratio) clinico-pathologic variables (age, T stage, multifocality, extensive intraductal carcinoma component (EIC), estrogen receptor, progesterone receptor, HER-2 status, Ki-67, molecular subtype, histologic grade, and nuclear grade) were compared between patients with axillary lymph node metastasis and those with no lymph node metastasis. Multivariate regression analysis was performed, to determine independent variables associated with ALN metastasis, and the area under the receiver operating characteristic curve (AUC), for predicting ALN metastasis was analyzed, for those variables. Results: On breast MRI, moderate or prominent ipsilateral whole-breast vascularity (moderate, odds ratio [OR] 3.45, 95% confidence interval [CI] 1.28-9.51 vs. prominent, OR = 15.59, 95% CI 2.52-96.46), SER (OR = 1.68, 95% CI 1.09-2.59), and peritumor-tumor ADC ratio (OR = 6.77, 95% CI 2.41-18.99), were independently associated with ALN metastasis. Among clinico-pathologic variables, HER-2 positivity was independently associated, with ALN metastasis (OR = 23.71, 95% CI 10.50- 53.54). The AUC for combining selected MRI variables and clinico-pathologic variables, was higher than that of clinico-pathologic variables (P < 0.05). Conclusion: SER, moderate or prominent increased whole breast vascularity, and peritumor-tumor ADC ratio on breast MRI, are valuable in predicting ALN metastasis, in patients with early stage of breast cancer.
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참고문헌 (31)
참고문헌 신청
박은화 / 2017 / Basic Facts of Breast Cancer in Korea in 2014: The 10-Year Overall Survival Progress / Journal of Breast Cancer 20(1):1~11
Kuijs VJ / 2015 / The role of MRI in axillary lymph node imaging in breast cancer patients: a systematic review / Insights Imaging 6:203~215
Qiu SQ / 2016 / A nomogram to predict the probability of axillary lymph node metastasis in early breast cancer patients with positive axillary ultrasound / Sci Rep 6:21196
Roaten JB / 2005 / Identifying risk factors for complications following sentinel lymph node biopsy for melanoma / Arch Surg 140:85~89
Giuliano AE / 2011 / Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial / JAMA 305:569~575
Kuijs VJ / 2015 / The role of MRI in axillary lymph node imaging in breast cancer patients: a systematic review / Insights Imaging 6:203~215
Qiu SQ / 2016 / A nomogram to predict the probability of axillary lymph node metastasis in early breast cancer patients with positive axillary ultrasound / Sci Rep 6:21196
Roaten JB / 2005 / Identifying risk factors for complications following sentinel lymph node biopsy for melanoma / Arch Surg 140:85~89
Giuliano AE / 2011 / Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial / JAMA 305:569~575
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