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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 195 - 200 (6page)
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초록· 키워드
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The purpose of this study was to investigate the melanogenesis inhibiting activity of the ethanol extract from Polygonum amphibium L. Firstly, the n-hexane (Hx), chloroform (CHCl3), ethyl acetate (EA), n-butanol (BuOH), and water (Water) fractions were isolated from the P. amphibium L. ethanol extract. The efficacy of melanogenesis was found to significantly decrease via the EA and BuOH fractions when compared to the control in B16F10 cells. EA particularly showed the lowest melanin content in B16F10 cells when compared to all the other extracts. Concentration-dependent inhibition of melanin synthesis was also observed in the EA fraction at concentrations below 50 μg/ml, which did not exhibit cytotoxicity in B16F10 cells. Notably, the expression of three key proteins (tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2), which are involved in melanogenesis, were significantly decreased via the EA fraction. EA also inhibited body pigmentation in vivo in a zebrafish model. Overall, we demonstrated melanogenesis suppression using the EA fraction from P. amphibium L., which could be a potential candidate for an antimelanogenesis agent.
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참고문헌 (20)
참고문헌 신청
Gao Yaqian / 2013 / 엽록체 DNA 염기서열에 근거한 물여뀌 종집단(마디풀과)의 분류학적 연구 / 식물분류학회지 43(1):34~45
Smolarz HD / 2003 / Influence of quercetin- 3-methyl ether from Polygonum amphibium on activation lymphocytes from peripheral blood of healthy donor in vitro / Phytother. Res 17:744~747
Smolarz HD / 2008 / Flavonoid glucuronides with anti-leukaemic activity from Polygonum amphibium L / Phytochem. Anal 19:506~513
권성호 / 2012 / 수생관속식물의 라디칼 소거능과 남세균 생장에 대한 억제활성 비교 / 생태와 환경 45(1):11~20
Tsatmali M / 2002 / Melanocyte function and its control by melanocortin peptides / J. Histochem. Cytochem 50:125~133
Smolarz HD / 2003 / Influence of quercetin- 3-methyl ether from Polygonum amphibium on activation lymphocytes from peripheral blood of healthy donor in vitro / Phytother. Res 17:744~747
Smolarz HD / 2008 / Flavonoid glucuronides with anti-leukaemic activity from Polygonum amphibium L / Phytochem. Anal 19:506~513
권성호 / 2012 / 수생관속식물의 라디칼 소거능과 남세균 생장에 대한 억제활성 비교 / 생태와 환경 45(1):11~20
Tsatmali M / 2002 / Melanocyte function and its control by melanocortin peptides / J. Histochem. Cytochem 50:125~133
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