Clinical importance of preoperative and postoperative prognostic nutritional index in patients with pancreatic ductal adenocarcinoma

Masahide Ikeguchi; Keisuke Goto; June Watanabe; Shoichi Urushibara; Tomohiro Osaki; Kanenori Endo; Shigeru Tatebe; Seiichi Nakamura

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자료유형: 학술저널

저자정보: Masahide Ikeguchi (Tottori Prefectural Central Hospital) Keisuke Goto (Tottori Prefectural Central Hospital) June Watanabe (Tottori Prefectural Central Hospital) Shoichi Urushibara (Tottori Prefectural Central Hospital) Tomohiro Osaki (Tottori Prefectural Central Hospital) Kanenori Endo (Tottori Prefectural Central Hospital) Shigeru Tatebe (Tottori Prefectural Central Hospital) Seiichi Nakamura (Tottori Prefectural Central Hospital)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제23권 제4호

발행연도: 2019.11

수록면: 372 - 376 (5page)

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Backgrounds/Aims: The prognostic nutritional index (PNI) is based on the albumin concentration and absolute lymphocyte count and is designed to assess the nutritional and immunological status of patients. In this study, we evaluated the prognostic importance of the preoperative and postoperative PNI in patients who underwent curative resection of pancreatic ductal adenocarcinoma (PDAC). Methods: From 2006 to 2017, 50 patients with PDAC underwent curative resection at our hospital. We performed distal pancreatectomy (DP) with splenectomy in 15 patients, pancreaticoduodenectomy (PD) in 27 patients, PD combined with portal vein partial resection in 6 patients, and total pancreatectomy with splenectomy in 2 patients. We compared the preoperative PNI and postoperative PNI (1 and 2 months postoperatively) and analyzed the prognostic importance for these patients. Results: The mean PNI significantly decreased from 45.5 preoperatively to 39.8 at 1 month postoperatively (p＜0.001), but recovered to 42.7 at 2 months postoperatively. In 23 patients, the PNI at 2 months postoperatively recovered to the preoperative level (recovered group), but in the remaining 27 patients, the PNI at 2 months postoperatively did not reach the preoperative level (non-recovered group). The overall median survival time in the recovered group (29 months) was significantly longer than that in the non-recovered group (12 months, p=0.003). The multivariate overall analysis demonstrated that good recovery of the postoperative PNI was strongly correlated with a better prognosis. Conclusions: Effective postoperative nutrition may have a prognostic benefit for patients with operable PDAC.

#Overall survival #Pancreatic ductal adenocarcinoma #Prognostic nutritional index

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