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사회과학
자연과학
공학
의약학
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예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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지원사업
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커뮤니티
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초록·키워드
The purpose of this study is to recognize the expression of autophagy and GLUT4 in T2DM white rats after eight weeks of accoding to exercise intensity training.
Type 2 diabetes was induced in rats by a combination of low dose streptozotocin(STZ; 40mg/kg) and feeding of a high fat diet. They were classified into four groups (Control(N=10), low-intensity exercise (N=10), middle-intensity(N=10) and high-intensity(N=10)). The male SD rats(N=40) ran on the treadmill with the intensity of 9~26m/min(40%~80% VO2max) with the slope of ten degrees. The exercise was performed for 60min/day, 5times/week during 8 weeks. The expression of GLUT4, p62, m-Tor, Beclin1and LC3 in the Gastrocnemius(GM) muscle was determined by Western blotting.
In the expression of significantly high manifestations in the middle-intensity group compared with other groups in GLUT4, Beclin and LC3. On the other hand, p62 and m-tor showed lower manifestations in all groups compared to control group.
These results are thought to be able to increase the expression of autophagy along with the effect of improving insulin sensitivity in the T2DM white rat muscles through exercise. In addition, medium and high-intensity exercise is considered to be more effective in activating this mechanism than low-intensity exercise.
Type 2 diabetes was induced in rats by a combination of low dose streptozotocin(STZ; 40mg/kg) and feeding of a high fat diet. They were classified into four groups (Control(N=10), low-intensity exercise (N=10), middle-intensity(N=10) and high-intensity(N=10)). The male SD rats(N=40) ran on the treadmill with the intensity of 9~26m/min(40%~80% VO2max) with the slope of ten degrees. The exercise was performed for 60min/day, 5times/week during 8 weeks. The expression of GLUT4, p62, m-Tor, Beclin1and LC3 in the Gastrocnemius(GM) muscle was determined by Western blotting.
In the expression of significantly high manifestations in the middle-intensity group compared with other groups in GLUT4, Beclin and LC3. On the other hand, p62 and m-tor showed lower manifestations in all groups compared to control group.
These results are thought to be able to increase the expression of autophagy along with the effect of improving insulin sensitivity in the T2DM white rat muscles through exercise. In addition, medium and high-intensity exercise is considered to be more effective in activating this mechanism than low-intensity exercise.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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