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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 306 - 316 (11page)
- DOI
- 10.7841/ksbbj.2019.34.4.306
이용수
이 논문의 연구 히스토리 (2)
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초록· 키워드
오류제보하기
This study has developed a new simplicity toxicity assessment method that can predict the chronic NOEC (No Observed Effect Concentration) value rapidly by observing the morphological abnormality at the low concentration area in the early embryonic development stage of Danio rerio. As a result, the acute LOEC (Lowest Observed Effect Concentration) values of Camptothecin, Camphor and Curcumin were calculated as 9.3 nM, 1248.4 μM and 18.3 μM, respectively. The morphological anomalies were observed to yolk sac edema (YSE), pericardial edema (PE), black yolk (BY), bent spine (BS), albinism (A), dyed yellow yolk (DY), collapse symptoms of fertilized embryo tissue (CPFE), no heartbeat (NHB), reduced heart rate (RHR), hatching delay (HD), short body length (SBL). And acute NOEC values were classified into A-type and B-type depending on the presence or absence of morphological anomalies. A-type morphological anomalies were observed at 6.2 nM, 832.3 μM and 9.2 μM, similar to the area near acute LOEC except for albinism (A), dyed yellow yolk (DY), collapse symptoms of fertilized embryo tissue (CPFE), and no heartbeat (NHB). On the other hand, morphological anomalies of B-type did not occur at all in 0.4, 4.0, and 0.1 within 4 days, and the acute NOEC values of B-type were consistent with the chronic NOEC values at 32 days. This means that the concentration without any deformity in acute toxicity test during 4 days is consistent with the chronic NOEC value. That is, it is also a means to quickly calculate chronic NOEC using the acute NOEC value through the presence or absence of morphological abnormality in the Danio rerio embryo development stage of short term.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (23)
참고문헌 신청
Ministry of Environment / An initial risk assessment commentary using chemical emissions information
National Institute of Environmental Research / Guidance on the selection criteria, procedures and methods, etc. of substances subject to risk assessment
National Institute of Environmental Research / The regulation on specific methods of chemical risk assessment
Park, J. G. / 2016 / A study on the support method of the act on registration and evaluation, etc. of chemical substances (ARECs) by analyzing EU REACH test data
OECD / 2013 / OECD guidelines for the testing of chemicals. Section 2: Effects on biotic systems test No. 210: Fish, early-life stage toxicity test / Organization for economic cooperation and development
National Institute of Environmental Research / Guidance on the selection criteria, procedures and methods, etc. of substances subject to risk assessment
National Institute of Environmental Research / The regulation on specific methods of chemical risk assessment
Park, J. G. / 2016 / A study on the support method of the act on registration and evaluation, etc. of chemical substances (ARECs) by analyzing EU REACH test data
OECD / 2013 / OECD guidelines for the testing of chemicals. Section 2: Effects on biotic systems test No. 210: Fish, early-life stage toxicity test / Organization for economic cooperation and development
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UCI(KEPA) : I410-ECN-0101-2020-470-000264726