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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 19 - 35 (17page)
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Campylobacter is a worldwide foodborne pathogen, associated with human gastroenteritis. The efficient translocation of Campylobacter and its ability to secrete toxins into host cells are the 2 key features of Campylobacter pathophysiology which trigger inflammation in intestinal cells and contribute to the development of gastrointestinal symptoms, particularly diarrhoea, in humans. The purpose of conducting this literature review is to summarise the current understanding of: i) the human immune responses involved in the elimination of Campylobacter infection and ii) the resistance potential in Campylobacter against these immune responses. This review has highlighted that the intestinal epithelial cells are the preliminary cells which sense Campylobacter cells by means of their cell-surface and cytosolic receptors, activate various receptorsdependent signalling pathways, and recruit the innate immune cells to the site of inflammation. The innate immune system, adaptive immune system, and networking between these systems play a crucial role in bacterial clearance. Different cellular constituents of Campylobacter, mainly cell membrane lipooligosaccharides, capsule, and toxins, provide protection to Campylobacter against the human immune system mediated killing. This review has also identified gaps in knowledge, which are related to the activation of following during Campylobacter infection: i) cathelicidins, bactericidal permeability-increasing proteins, chemokines, and inflammasomes in intestinal epithelial cells; ii) siglec-7 receptors in dendritic cell; iii) acute phase proteins in serum; and iv) T-cell subsets in lymphoid nodules. This review evaluates the existing literature to improve the understanding of human immunity against Campylobacter infection and identify some of the knowledge gaps for future research.
목차
ABSTRACT
INTRODUCTION
INDUCTION OF SIGNALLING PATHWAYS IN INTESTINAL MUCOSA FOR PATHOGEN RECOGNITION
INFLUX OF PROFESSIONAL PHAGOCYTES INTO SUBMUCOSA FOR BACTERIAL CLEARANCE
ACTIVATION OF ADAPTIVE IMMUNITY FOR PERSISTENT INFECTION
ACTIVATION OF SERUM PROTEINS FOR PERSISTENT INFECTION
NETWORKING BETWEEN HUMAN CELLS DURING CAMPYLOBACTER INFECTION
GAPS IN KNOWLEDGE FOR FUTURE RESEARCH
REFERENCES
참고문헌 (119)
참고문헌 신청
Skirrow MB / 1977 / Campylobacter enteritis: a “new” disease / BMJ 2:9~11
Havelaar AH / 2010 / World Health Organization global estimates and regional comparisons of the burden of foodborne disease in 2010 / PLoS Med 12:e1001923
Humphrey S / 2014 / Campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare / MBio 5:e01364~e01314
Han Z / 2016 / Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken / Gut Pathog 8:56
Han Z / 2017 / Influence of the gut microbiota composition on Campylobacter jejuni colonization in chickens / Infect Immun 85:e00380~e00317
Havelaar AH / 2010 / World Health Organization global estimates and regional comparisons of the burden of foodborne disease in 2010 / PLoS Med 12:e1001923
Humphrey S / 2014 / Campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare / MBio 5:e01364~e01314
Han Z / 2016 / Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken / Gut Pathog 8:56
Han Z / 2017 / Influence of the gut microbiota composition on Campylobacter jejuni colonization in chickens / Infect Immun 85:e00380~e00317
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UCI(KEPA) : I410-ECN-0101-2020-517-000376110