지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.98 No.3
- 발행연도
- 2020.3
- 수록면
- 116 - 123 (8page)
이용수
초록· 키워드
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Purpose: Hepatic resection is considered as the optimal treatment for intrahepatic cholangiocarcinoma (IHCC); however, the survival rate after resection is low and the analysis of long-term (≥10 years) survivors is rare. This study aims to analyze the clinicopathological factors affecting the long-term survival of patients with IHCC.
Methods: Between January 2003 and December 2012, a single-institution cohort of 429 patients who underwent hepatic resection for IHCC were reviewed retrospectively. Surgical results, recurrence, and survival rates were investigated, and multivariate analyses were performed to identify prognostic factors.
Results: The overall 1- , 3- , 5- and 10-year survival rates of patients were 76.5%, 44.1%, 33.3%, and 25.1%, respectively. Multivariate analysis showed that the serum CA 19-9 level (≥38 U/mL) (P < 0.001), lymph node (LN) metastasis (P = 0.001), and lymphovascular invasion (LVI) (P = 0.012) were independent factors associated with overall survival. In particular, CA 19-9 level and histologic type were determined to be independent factors affecting survival for more than 10 years.
Conclusion: CA 19-9 (≥38 U/mL), LN metastasis, and LVI were identified as independent risk factors for survival after resection of IHCC. CA 19-9 (<38 U/mL) and histologic type were independent factors predicting survival for more than 10 years.
Methods: Between January 2003 and December 2012, a single-institution cohort of 429 patients who underwent hepatic resection for IHCC were reviewed retrospectively. Surgical results, recurrence, and survival rates were investigated, and multivariate analyses were performed to identify prognostic factors.
Results: The overall 1- , 3- , 5- and 10-year survival rates of patients were 76.5%, 44.1%, 33.3%, and 25.1%, respectively. Multivariate analysis showed that the serum CA 19-9 level (≥38 U/mL) (P < 0.001), lymph node (LN) metastasis (P = 0.001), and lymphovascular invasion (LVI) (P = 0.012) were independent factors associated with overall survival. In particular, CA 19-9 level and histologic type were determined to be independent factors affecting survival for more than 10 years.
Conclusion: CA 19-9 (≥38 U/mL), LN metastasis, and LVI were identified as independent risk factors for survival after resection of IHCC. CA 19-9 (<38 U/mL) and histologic type were independent factors predicting survival for more than 10 years.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Dodson RM / 2013 / Intrahepatic cholangiocarcinoma : management options and emerging therapies / J Am Coll Surg 217:736~750
Khan SA / 2008 / Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma / HPB(Oxford) 10:77~82
Poultsides GA / 2010 / Intrahepatic cholangiocarcinoma / Surg Clin North Am 90:817~837
Sempoux C / 2011 / Intrahepatic cholangiocarcinoma : new insights in pathology / Semin Liver Dis 31:49~60
Tan JC / 2008 / Surgical management of intrahepatic cholangiocarcinoma--a population-based study / Ann Surg Oncol 15:600~608
Khan SA / 2008 / Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma / HPB(Oxford) 10:77~82
Poultsides GA / 2010 / Intrahepatic cholangiocarcinoma / Surg Clin North Am 90:817~837
Sempoux C / 2011 / Intrahepatic cholangiocarcinoma : new insights in pathology / Semin Liver Dis 31:49~60
Tan JC / 2008 / Surgical management of intrahepatic cholangiocarcinoma--a population-based study / Ann Surg Oncol 15:600~608
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UCI(KEPA) : I410-ECN-0101-2020-514-000449535