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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 560 - 568 (9page)
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초록· 키워드
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Purpose: This study evaluated the antibacterial effects of curcuma, ginger, and finger root extracts in water-soluble powder on planktonic Streptococcus mutans (S.mutans ), which is known to cause dental caries, in order to confirm whether these extracts could perform as photosensitizers for the effects of photodynamic therapy (PDT).
Methods: This study used the strain of streptococcus mutans ATCC 25175 distributed by the Korean Collection for Type Cultures of the Korea Research Institute of Bioscience & Biotechnology. Commercial edible curcuma, ginger and finger root were used as the natural extracts for the use of photosensitizer. To extract organic solvent, 3 g of each powder was mixed in 30 ㎖ of dimethyl sulfoxide (DMSO, VWR, Germany) before extraction. 1.8 ㎖ of the photosensitizer solution, manufactured in the concentrations of 5, 0.5, and 0.05 ㎎/㎖, was mixed with 0.2 ㎖ of the S. mutans culture medium that had been cultured for 2 days. To induce the photodynamic reaction, Qraycam (AIOBIO, Seoul, Korea) equipped with 405 ㎚ LED was used to expose light for 5 minutes to irradiate 59 ㎻ energy for 300 seconds.
Results: Compared with the case with no light, a higher photodynamic therapeutic effect was confirmed with 0.05㎎/㎖ curcuma powder extract, the concentration of 0.5 ㎎/㎖ and LED light of 405 ㎚ wavelength (p=0.000, p=0.003). 0.05 ㎎/㎖ of curcuma powder extract and the concentration of 0.5 ㎎/㎖ showed 100% antibacterial effect when exposed to light, whereas the concentration of 5 ㎎/㎖ showed 11.95% antibacterial effect. When exposed to light, 0.05 ㎎/㎖ of ginger powder extract showed an antibacterial effect which didn"t statistically decrease. The concentrations of 0.5 ㎎/㎖ and 5 ㎎/㎖ did not show any antibacterial effects. As a result of examining any photodynamic therapeutic effects of finger root powder extract on S. mutans , no statistically significant effect was found.
Conclusion: The curcuma powder extract is expected to perform as a photosensitizer. Even though belonging to the same ginger family, ginger powder and finger root powder seem difficult to perform as photosensitizer.
Methods: This study used the strain of streptococcus mutans ATCC 25175 distributed by the Korean Collection for Type Cultures of the Korea Research Institute of Bioscience & Biotechnology. Commercial edible curcuma, ginger and finger root were used as the natural extracts for the use of photosensitizer. To extract organic solvent, 3 g of each powder was mixed in 30 ㎖ of dimethyl sulfoxide (DMSO, VWR, Germany) before extraction. 1.8 ㎖ of the photosensitizer solution, manufactured in the concentrations of 5, 0.5, and 0.05 ㎎/㎖, was mixed with 0.2 ㎖ of the S. mutans culture medium that had been cultured for 2 days. To induce the photodynamic reaction, Qraycam (AIOBIO, Seoul, Korea) equipped with 405 ㎚ LED was used to expose light for 5 minutes to irradiate 59 ㎻ energy for 300 seconds.
Results: Compared with the case with no light, a higher photodynamic therapeutic effect was confirmed with 0.05㎎/㎖ curcuma powder extract, the concentration of 0.5 ㎎/㎖ and LED light of 405 ㎚ wavelength (p=0.000, p=0.003). 0.05 ㎎/㎖ of curcuma powder extract and the concentration of 0.5 ㎎/㎖ showed 100% antibacterial effect when exposed to light, whereas the concentration of 5 ㎎/㎖ showed 11.95% antibacterial effect. When exposed to light, 0.05 ㎎/㎖ of ginger powder extract showed an antibacterial effect which didn"t statistically decrease. The concentrations of 0.5 ㎎/㎖ and 5 ㎎/㎖ did not show any antibacterial effects. As a result of examining any photodynamic therapeutic effects of finger root powder extract on S. mutans , no statistically significant effect was found.
Conclusion: The curcuma powder extract is expected to perform as a photosensitizer. Even though belonging to the same ginger family, ginger powder and finger root powder seem difficult to perform as photosensitizer.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
Ⅴ. 결론
참고문헌
참고문헌 (29)
참고문헌 신청
Adolfsson Erici M / 2002 / Troclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden / Chemosphere 46(9-10):1485~1489
한국보건사회연구원 / 2016 / 항생제 내성
김백일 / 2005 / Curcuma xanthorrhiza 추출물 및 함유 치약의 구취 억제 효과와 구강 유해균에 대한 선택적 항균 효과 / 대한구강보건학회지 29(2):222~237
Aruoma OI / 1996 / An evaluation of the antioxidant and antiviralaction of extracts of rosemary and Provencal herbs / Food Chem Toxicol 34:449~456
Ann GW / 2004 / Clinical studies on the irrtation effects of Mung Bean(Phaseolus aureus) extractin cosmatics / J Soc Cosmet Scientist Kor 30:23~28
한국보건사회연구원 / 2016 / 항생제 내성
김백일 / 2005 / Curcuma xanthorrhiza 추출물 및 함유 치약의 구취 억제 효과와 구강 유해균에 대한 선택적 항균 효과 / 대한구강보건학회지 29(2):222~237
Aruoma OI / 1996 / An evaluation of the antioxidant and antiviralaction of extracts of rosemary and Provencal herbs / Food Chem Toxicol 34:449~456
Ann GW / 2004 / Clinical studies on the irrtation effects of Mung Bean(Phaseolus aureus) extractin cosmatics / J Soc Cosmet Scientist Kor 30:23~28
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