Anti-allergic Effects of Caffeine in an Allergic Rhinitis Mouse Model

Yan Jing Fan; Chun Hua Piao; Thi Van Nguyen; Zhen Nan Yu; Ok Hee Chai; Chang Ho Song

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자료유형: 학술저널

저자정보: Yan Jing Fan (Jeonbuk National University Medical School) Chun Hua Piao (Jeonbuk National University Medical School) Thi Van Nguyen (Jeonbuk National University Medical School) Zhen Nan Yu (Jeonbuk National University Medical School) Ok Hee Chai (Jeonbuk National University Medical School) Chang Ho Song (Jeonbuk National University Medical School,)

저널정보: 대한체질인류학회 해부·생물인류학 해부·생물인류학 제33권 제1호

발행연도: 2020.3

수록면: 11 - 19 (9page)

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Caffeine (1, 3, 7-trimethylxanthine) is one of the most widely consumed pharmacologically active products worldwide. Caffeine exhibits various pharmacological activities in central nervous, cardiovascular, and respiratory systems. Additionally, caffeine exhibited anti-inflammatory effects in lipopolysaccharide-challenged rats. However, to our knowledge, the potential anti-inflammatory activity of caffeine in allergic rhinitis (AR) has not yet been investigated. Therefore, in this study, we aimed to examine the anti-allergic effects of caffeine in ovalbumin (OVA)-induced AR in mice. We showed that caffeine attenuated the nasal symptoms, including rubbing and sneezing. It reduced the thickness of the nasal mucosa and alleviated goblet cell hyperplasia in the nasal mucosa. In addition, caffeine ameliorated the inflammation in the lungs and decreased OVA-specific immunoglobulin E (IgE) and IgG1 levels in the serum. It also reduced T helper type 2 (Th2) cytokine (interleukin (IL)-4 and IL-5) levels and elevated Th1 cytokine (IL-12 and IFN-γ) levels in the nasal lavage fluid. Collectively, we suggest that caffeine might have therapeutic effects in AR owing to its anti-inflammatory activities.

#Caffeine #Allergic rhinitis #Anti-allergic effects #Cytokines

참고문헌 (28)

참고문헌 신청

Wu S / 2019 / Effects of lentivirus-mediated CCR3 RNA interference on the function of mast cells of allergic rhinitis in mice / Int Immunopharmacol

Xiao B / 2020 / Ethno-medicinal study of Artemisia ordosica Krasch. (traditional Chinese/Mongolian medicine) extracts for the treatment of allergic rhinitis and nasosinusitis / J Ethnopharmacol

Yu-Lian Zhang / 2019 / Antiallergic Effect of Hizikia fusiformis in an Ovalbumin-Induced Allergic Rhinitis Mouse Model / Clinical and Experimental Otorhinolaryngology 12(2):196~205

Xu W / 2018 / Effects of anthraquinones from Cassia occidentalis L. on ovalbumin-induced airways inflammation in a mouse model of allergic asthma / J Ethnopharmacol 221:1~9

Lee JW / 2019 / Pistacia weinmannifolia root exerts a protective role in ovalbumininduced lung inflammation in a mouse allergic asthma model / Int J Mol Med 44:2171~2180

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