지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.1
- 발행연도
- 2020.3
- 수록면
- 65 - 70 (6page)
- DOI
- 10.3746/pnf.2020.25.1.65
이용수
초록· 키워드
오류제보하기
Diazinon is an imminent and hazardous chemical organophosphate multiplex that is generally used as a pesticide but is toxic for many species particularly vertebrates. Berberry (Berberis vulgaris L., family Berberidaceae) is a plant that flourishes in Europe and Asia that has been largely investigated for its therapeutic effects. In the present study, we evaluated the protective effects of B. vulgaris on diazinon-induced brain damage in young male mice. Twenty-one young male albino mice weighing 18±2 g were divided in three equal groups of seven mice, and treated orally with either olive oil (control), diazinon 50 mg/kg+B. vulgaris extract 200 mg/kg, or diazinon 50 mg/kg. After three weeks, cerebrum and cerebellum samples were collected for antioxidant assays. The results indicated that diazinon increased oxidative stress in the brain of mice. The glutathione content and proceedings of antioxidant enzymes, such as glutathione peroxidase, superoxide dismutase, and catalase, were significantly reduced in both the cerebellum and cerebrum of diazinon-treated mice, compared with the control group. In addition, acetylcholinesterase (AChE) activity was inhibited by exposure to this pesticide. Administration of 200 mg/kg B. vulgaris extract with diazinon significantly decreased oxidative stress indices in all experiments. The results indicated that B. vulgaris extract has protective effects against lipid peroxidation of the cerebellum and cerebrum, and in regenerating AChE activity in the brain induced by diazinon.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
Aebi H / 1984 / Catalase in vitro / Methods Enzymol 105:121~126
Ahmed RS / 2000 / Influence of dietary ginger(Zingiber officinales Rosc)on oxidative stress induced by malathion in rats / Food Chem Toxicol 38:443~450
Alavanja MC / 2013 / Increased cancer burden among pesticide applicators and others due to pesticide exposure / CA Cancer J Clin 63:120~142
Arayne MS / 2007 / The berberis story : Berberis vulgaris in therapeutics / Pak J Pharm Sci 20:83~92
Beauchamp C / 1971 / Superoxide dismutase : improved assays and an assay applicable to acrylamide gels / Anal Biochem 44:276~287
Ahmed RS / 2000 / Influence of dietary ginger(Zingiber officinales Rosc)on oxidative stress induced by malathion in rats / Food Chem Toxicol 38:443~450
Alavanja MC / 2013 / Increased cancer burden among pesticide applicators and others due to pesticide exposure / CA Cancer J Clin 63:120~142
Arayne MS / 2007 / The berberis story : Berberis vulgaris in therapeutics / Pak J Pharm Sci 20:83~92
Beauchamp C / 1971 / Superoxide dismutase : improved assays and an assay applicable to acrylamide gels / Anal Biochem 44:276~287
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UCI(KEPA) : I410-ECN-0101-2020-594-000508668