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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.3
- 수록면
- 215 - 221 (7page)
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초록· 키워드
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Background: Panax ginseng has been used for a variety of medical purposes in eastern countries for more than two thousand years. From the extensive experiences accumulated in its long medication use history and the substantial strong evidence in modern research studies, we know that ginseng has various pharmacological activities, such as antitumor, antidiabetic, antioxidant, and cardiovascular system-protective effects. The active chemical constituents of ginseng, ginsenosides, are rich in structural diversity and exhibit a wide range of biological activities.
Methods: Ginsenoside constituents from P. ginseng flower buds were isolated and purified by various chromatographic methods, and their structures were identified by spectroscopic analysis and comparison with the reported data. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H- tetrazolium bromide method was used to test their cytotoxic effects on three human cancer cell lines.
Results: Six ginsenosides, namely 6’emalonyl formyl ginsenoside F₁ (1), 3β-acetoxyl ginsenoside F₁ (2), ginsenoside Rh<SUB>24</SUB> (6), ginsenoside Rh<SUB>25</SUB> (7), 7β-hydroxyl ginsenoside Rd (8) and ginsenoside Rh<SUB>26</SUB> (10) were isolated and elucidated as new compounds, together with four known compounds (3-5 and 9). In addition, the cytotoxicity of these isolated compounds was shown as half inhibitory concentration values, a tentative structure-activity relationship was also discussed based on the results of our bioassay.
Conclusion: The study of chemical constituents was useful for the quality control of P. ginseng flower buds. The study on antitumor activities showed that new Compound 1 exhibited moderate cytotoxic activities against HL-60, MGC80-3 and Hep-G2 with half inhibitory concentration values of 16.74, 29.51 and 20.48 µM, respectively.
Methods: Ginsenoside constituents from P. ginseng flower buds were isolated and purified by various chromatographic methods, and their structures were identified by spectroscopic analysis and comparison with the reported data. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H- tetrazolium bromide method was used to test their cytotoxic effects on three human cancer cell lines.
Results: Six ginsenosides, namely 6’emalonyl formyl ginsenoside F₁ (1), 3β-acetoxyl ginsenoside F₁ (2), ginsenoside Rh<SUB>24</SUB> (6), ginsenoside Rh<SUB>25</SUB> (7), 7β-hydroxyl ginsenoside Rd (8) and ginsenoside Rh<SUB>26</SUB> (10) were isolated and elucidated as new compounds, together with four known compounds (3-5 and 9). In addition, the cytotoxicity of these isolated compounds was shown as half inhibitory concentration values, a tentative structure-activity relationship was also discussed based on the results of our bioassay.
Conclusion: The study of chemical constituents was useful for the quality control of P. ginseng flower buds. The study on antitumor activities showed that new Compound 1 exhibited moderate cytotoxic activities against HL-60, MGC80-3 and Hep-G2 with half inhibitory concentration values of 16.74, 29.51 and 20.48 µM, respectively.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (34)
참고문헌 신청
Nag SA / 2012 / Ginsenosides as anticancer agents : in vitro and in vivo activities, structureeactivity relationships, and molecular mechanisms of action / Front Pharmacol 3:25
Wang CZ / 2015 / Ginseng metabolites on cancer chemoprevention : an angiogenesis link / Diseases 3:193~204
Li KK / 2015 / A review on the medicinal potentials of Panax ginseng saponins in diabetes mellitus / RSC Adv 5:47353~47366
이창호 / 2014 / A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases / Journal of Ginseng Research 38(3):161~166
Ru W / 2015 / Chemical constituents and bioactivities of Panax ginseng(C. A. Mey.) / Drug Discov Ther 9:23~32
Wang CZ / 2015 / Ginseng metabolites on cancer chemoprevention : an angiogenesis link / Diseases 3:193~204
Li KK / 2015 / A review on the medicinal potentials of Panax ginseng saponins in diabetes mellitus / RSC Adv 5:47353~47366
이창호 / 2014 / A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases / Journal of Ginseng Research 38(3):161~166
Ru W / 2015 / Chemical constituents and bioactivities of Panax ginseng(C. A. Mey.) / Drug Discov Ther 9:23~32
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UCI(KEPA) : I410-ECN-0101-2020-524-000504495