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논문 기본 정보

자료유형
학술저널
저자정보
Laura Rojas Lorz (Sungkyunkwan University) Mi-Yeon Kim (Soongsil University) Jae Youl Cho (Sungkyunkwan University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.44 No.1
발행연도
2020.1
수록면
8 - 13 (6page)

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초록· 키워드

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Atopic dermatitis (AD) is a chronic and relapsing inflammatory disease that affects 1%-20% of people worldwide. Despite affecting many people, AD current treatments, such as corticosteroids and calcineurin inhibitors, have not only harmful secondary effects but are also often ineffective. Therefore, natural nontoxic compounds are on high demand for developing new effective AD treatments. Panax ginseng Meyer has been used traditionally for its promising healing and restorative properties to treat many diseases including skin disorders, reason why in this review we want to explore the research performed with AD and P. ginseng as well as determining its potential for new drug development. Previous researches have shown that P. ginseng has positive effects in AD patients such as lower eczema area and severity index, transepidermal water loss, and immunoglobulin E levels and better quality of sleep. In vivo animal models, as well, have shown positive results to P. ginseng and derived ginsenosides, such as the decrease of transepidermal water loss, immunoglobulin E levels in serum, allergy-related cytokines, and downregulation of NF-kB, MAPK, and Ikaros pathways. All of these previous data suggest that P. ginseng and its derived ginsenosides are undoubtedly a nontoxic effective option to treat AD.

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ABSTRACT
1. Introduction
2. AD pathology and mechanism of action
3. Commonly used AD treatments
4. Use of P. ginseng extract and ginsenosides in AD treatment
5. Concluding remarks and future perspectives
References

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UCI(KEPA) : I410-ECN-0101-2020-524-000504713