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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 133 - 141 (9page)
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초록· 키워드
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The epidermal growth factor receptor (EGFR), a member of the ErbB family (EGFR, ErbB2, ErbB3 and ErbB4), plays a crucial role in regulating various cellular responses such as proliferation, differentiation, and survival. As a result, aberrant activation of EGFR, mostly mediated through different classes of genomic alterations occurring within EGFR, is closely associated with the pathogenesis of numerous human cancers including lung adenocarcinoma, glioblastoma, and colorectal cancer. Thus, specific suppression of oncogenic activity of mutant EGFR with its targeted drugs has been routinely used in the clinic as a very effective anti-cancer strategy in treating a subset of tumors driven by such oncogenic EGFR mutants. However, the clinical efficacy of EGFR-targeted therapy does not last long due to several resistance mechanisms that emerge in the patients following the drug treatment. Thus, there is an urgent need for the development of novel therapeutic tactics specifically targeting mutant EGFR with the focus on the unique biological features of various mutant EGFR. Regarding this point, our review specifically emphasizes the recent findings about distinct requirements of receptor dimerization and autophosphorylation, which are critical steps for enzymatic activation of EGFR and signaling cascades, respectively, among wildtype and mutant EGFR and further discuss their clinical significance. In addition, the molecular mechanisms regulating EGFR dimerization and enzymatic activity by a key negative feedback inhibitor Mig6 as well as the clinical use for developing potential novel drugs targeting it are described in this review.
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참고문헌 (72)
참고문헌 신청
Olayioye MA / 2000 / The ErbB signaling network : receptor heterodimerization in development and cancer / EMBO J 19:3159~3167
Yarden Y / 2012 / The ERBB network : at last, cancer therapy meets systems biology / Nat Rev Cancer 12:553~563
Schlessinger J / 2006 / Nuclear signaling by receptor tyrosine kinases : the first robin of spring / Cell 127:45~48
Burgess AW / 2003 / An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors / Mol Cell 12:541~552
Schlessinger J / 2000 / Cell signaling by receptor tyrosine kinases / Cell 103:211~225
Yarden Y / 2012 / The ERBB network : at last, cancer therapy meets systems biology / Nat Rev Cancer 12:553~563
Schlessinger J / 2006 / Nuclear signaling by receptor tyrosine kinases : the first robin of spring / Cell 127:45~48
Burgess AW / 2003 / An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors / Mol Cell 12:541~552
Schlessinger J / 2000 / Cell signaling by receptor tyrosine kinases / Cell 103:211~225
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