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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 739 - 746 (8page)
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초록· 키워드
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Significant knowledge about the pathophysiology of Alzheimer’s disease (AD) has been gained in the last century; however, the understanding of its causes of onset remains limited. Late-onset AD is observed in about 95% of patients, and APOE4-encoding apolipoprotein E4 (ApoE4) is strongly associated with these cases. As an apolipoprotein, the function of ApoE in brain cholesterol transport has been extensively studied and widely appreciated. Development of new technologies such as human-induced pluripotent stem cells (hiPSCs) and CRISPR-Cas9 genome editing tools have enabled us to develop human brain model systems in vitro and readily manipulate genomic information. In the context of these advances, recent studies provide strong evidence that abnormal cholesterol metabolism by ApoE4 could be linked to AD-associated pathology. In this review, we discuss novel discoveries in brain cholesterol dysregulation by ApoE4. We further elaborate cell type-specific roles in cholesterol regulation of four major brain cell types, neurons, astrocytes, microglia, and oligodendrocytes, and how its dysregulation can be linked to AD pathology.
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참고문헌 (92)
참고문헌 신청
Abud, E. M. / 2017 / iPSC-derived human microglia-like cells to study neurological diseases / Neuron 94:278.e9~293.e9
Baik, S. H. / 2019 / A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer's disease / Cell Metab 30:493.e6~507.e6
Bales, K. R. / 1997 / Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition / Nat. Genet 17:263~264
Bell, R. D. / 2012 / Apolipoprotein E controls cerebrovascular integrity via cyclophilin A / Nature 485:512~516
Benarroch, E. E. / 2008 / Brain cholesterol metabolism and neurologic disease / Neurology 71:1368~1373
Baik, S. H. / 2019 / A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer's disease / Cell Metab 30:493.e6~507.e6
Bales, K. R. / 1997 / Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition / Nat. Genet 17:263~264
Bell, R. D. / 2012 / Apolipoprotein E controls cerebrovascular integrity via cyclophilin A / Nature 485:512~516
Benarroch, E. E. / 2008 / Brain cholesterol metabolism and neurologic disease / Neurology 71:1368~1373
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