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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 304 - 311 (8page)
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Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was reduced. When we measured the expression levels of AMP genes during aging, those were getting increased in the control flies but reduced in MRS inhibition flies agedependently. Interestingly, in the germ-free condition, the maximum lifespan was increased in MRS inhibition flies compared with that of the conventional condition. These findings suggest that the lifespan of MRS inhibition flies is reduced due to the down-regulated AMPs expression in Drosophila.
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참고문헌 (37)
참고문헌 신청
Badinloo, M. / 2018 / Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues / Arch. Insect Biochem. Physiol 98:e21464
Barcena, C. / 2018 / Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism / Cell Rep 24:2392~2403
Becker, T. / 2010 / FOXO-dependent regulation of innate immune homeostasis / Nature 463:369~373
Bjedov, I. / 2010 / Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster / Cell Metab 11:35~46
Broughton, S. / 2009 / Insulin/IGF-like signalling, the central nervous system and aging / Biochem. J 418:1~12
Barcena, C. / 2018 / Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism / Cell Rep 24:2392~2403
Becker, T. / 2010 / FOXO-dependent regulation of innate immune homeostasis / Nature 463:369~373
Bjedov, I. / 2010 / Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster / Cell Metab 11:35~46
Broughton, S. / 2009 / Insulin/IGF-like signalling, the central nervous system and aging / Biochem. J 418:1~12
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