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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 441 - 448 (8page)
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초록· 키워드
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This study was aimed at identifying the lower airway microbiota in patients with lung cancer (LC) using protected brush sampling. We enrolled 37 patients undergoing diagnostic bronchoscopy for suspected LC, 26 with LC and 11 with benign diseases. Protected brush specimens were obtained from the contralateral lung and the side of the tumor; these specimens were analyzed by 16S rRNA-based-next-generation sequencing. The results indicated that the biodiversity was not different between groups, and there were no significant differences between the proportion of microorganisms in the tumor and in the contralateral side of patients with LC. In patients with LC, there was a higher abundance of several microorganisms including Capnocytophaga, Haemophilus, Enterococcus, and Streptococcus; whereas, in individuals without LC, Bacteroides, Lactobacillus, or Methylobacterium were more abundant. Malignancy could be determined with an accuracy of 70% by isolating Enterococcus, Capnocytophaga, or Actinomyces. Microbispora indicated benignity with a sensitivity of 55%, specificity of 88%, and accuracy of 78%. Lower airway microbiota in patients with LC is fairly similar in both the tumor and contralateral sites. Endobronchial microbiota is different in patients with and without LC, and these differences may have a potential clinical value as diagnostic or prognostic biomarkers.
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참고문헌 (32)
참고문헌 신청
Lynch SV / 2016 / The human intestinal microbiome in health and disease / N. Engl. J. Med 375:2369~2379
Pevsner-Fischer M / 2016 / 2016. Role of the microbiome in non-gastrointestinal cancers / World J. Clin. Oncol 7:200~213
Vogtmann E / 2016 / Epidemiologic studies of the human microbiome and cancer / Br. J. Cancer 114:237~242
Schwabe RF / 2013 / The microbiome and cancer / Nat. Rev. Cancer 13:800~812
Nugent JL / 2014 / Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas / J. Proteome Res 13:1921~1929
Pevsner-Fischer M / 2016 / 2016. Role of the microbiome in non-gastrointestinal cancers / World J. Clin. Oncol 7:200~213
Vogtmann E / 2016 / Epidemiologic studies of the human microbiome and cancer / Br. J. Cancer 114:237~242
Schwabe RF / 2013 / The microbiome and cancer / Nat. Rev. Cancer 13:800~812
Nugent JL / 2014 / Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas / J. Proteome Res 13:1921~1929
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