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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제10호
- 발행연도
- 2019.1
- 수록면
- 1,675 - 1,681 (7page)
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Clostridium difficile toxin A is known to cause colonic epithelial cell apoptosis, which is considered the main causative event that triggers inflammatory responses in the colon, reflecting the concept that the essential role of epithelial cells in the colon is to form a physical barrier in the gut. We previously showed that toxin A-induced colonocyte apoptosis and subsequent inflammation were dependent on prostaglandin E2 (PGE2) produced in response to toxin A stimulation. However, the molecular mechanism by which PGE2 mediates cell apoptosis in toxin A-exposed colonocytes has remained unclear. Here, we sought to identify the signaling pathway involved in toxin A-induced, PGE2-mediated colonocyte apoptosis. In non-transformed NCM460 human colonocytes, toxin A exposure strongly upregulated expression of Bak, which is known to form mitochondrial outer membrane pores, resulting in apoptosis. RT-PCR analyses revealed that this increase in Bak expression was attributable to toxin A-induced transcriptional upregulation. We also found that toxin A upregulation of Bak expression was dependent on PGE2 production, and further showed that this effect was recapitulated by an Prostaglandin E2(PGE2) receptor-1 receptor agonist, but not by agonists of other EP receptors. Collectively, these results suggest that toxin A-induced cell apoptosis involves PGE2-upregulation of Bak through the EP1 receptor.
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참고문헌 (41)
참고문헌 신청
Kim H / 2007 / Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand / Gastroenterology 133:875~886
Kim H / 2005 / Clostridium difficile toxin A-induced colonocyte apoptosis involves pp,53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase / Gastroenterology 129:1875~1888
Kim H / 2005 / Clostridium difficile toxin a regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK / J. Biol. Chem 280:21237~21245
He D / 2002 / Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation / Gastroenterology 122:1048~1057
Kim DH / 2016 / The insect peptide CopA3 increases colonic epithelial cell proliferation and mucosal barrier function to prevent inflammatory responses in the gut / J. Biol. Chem 291:3209~3223
Kim H / 2005 / Clostridium difficile toxin A-induced colonocyte apoptosis involves pp,53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase / Gastroenterology 129:1875~1888
Kim H / 2005 / Clostridium difficile toxin a regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK / J. Biol. Chem 280:21237~21245
He D / 2002 / Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation / Gastroenterology 122:1048~1057
Kim DH / 2016 / The insect peptide CopA3 increases colonic epithelial cell proliferation and mucosal barrier function to prevent inflammatory responses in the gut / J. Biol. Chem 291:3209~3223
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