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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제1호
- 발행연도
- 2020.1
- 수록면
- 38 - 43 (6page)
이용수
초록· 키워드
오류제보하기
Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 μg/ml) and 106 PFU/ml of EV71. SalB treatment (100 μg/ml) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescence staining. The Akt signaling pathway, a key component of cell survival and proliferation, was significantly increased in EV71-infected HeLa cells treated with 100 μg/ml SalB. RT-PCR results showed that the mRNA for anti-apoptotic protein Bcl-2 and the cell cycle regulator Cyclin-D1 were significantly increased by SalB treatment. These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. Taken together, these results suggest that SalB could be used to develop a new therapeutic drug for EV71-induced HFMD.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Wang QQ / 2019 / Salvianolic acid B inhibits the development of diabetic peripheral neuropathy by suppressing autophagy and apoptosis / J. Pharm. Pharmacol 71:417~428
Liu P / 2002 / Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B / World J. Gstroenterol 8:679~685
Lin YL / 2006 / In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells / J. Ethnopharmacol 105:215~222
Chen YH / 2000 / Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats / Acta Pharmacol. Sin 21:463~466
Zhao GR / 2008 / Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B / Food Chem. Toxicol 46:73~81
Liu P / 2002 / Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B / World J. Gstroenterol 8:679~685
Lin YL / 2006 / In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells / J. Ethnopharmacol 105:215~222
Chen YH / 2000 / Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats / Acta Pharmacol. Sin 21:463~466
Zhao GR / 2008 / Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B / Food Chem. Toxicol 46:73~81
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