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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제1호
- 발행연도
- 2020.1
- 수록면
- 11 - 20 (10page)
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초록· 키워드
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Quercetin and its derivatives are important metabolites that belong to the flavonol class of flavonoids. Quercetin and some of the conjugates have been approved by the FDA for human use. They are widely distributed among plants and have various biological activities, such as being anticancer, antiviral, and antioxidant. Hence, the biosynthesis of novel derivatives is an important field of research. Glycosylation and methylation are two important modification strategies that have long been used and have resulted in many novel metabolites that are not present in natural sources. A strategy for modifying quercetin in E. coli by means of glycosylation, for example, involves overexpressing respective glycosyltransferases (GTs) in the host and metabolic engineering for increasing nucleoside diphosphate sugar (NDP-sugar). Still others have used microorganisms other than E. coli, such as Streptomyces sp., for the biotransformation process. The overall study of the structural activity relationship has revealed that modification of some residues in quercetin decreased one activity but increased others. This review summarizes all of the information mentioned above.
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참고문헌 (30)
참고문헌 신청
Nemeth K / 2007 / Food content, processing, absorption and metabolism of onion flavonoids / Crit. Rev. Food Sci. Nutr 47:397~409
Berardini N / 2005 / Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins and pectin / J. Agric. Food Chem. 53:1563~1570
Ramalho SD / 2015 / Evaluation of flavonols and derivatives as human cathepsin B inhibitor / Nat. Prod. Res 29:2212~2214
Qiu X / 2016 / Prophylactic efficacy of quercetin 3-β-OD-glucoside against Ebola virus infection / Antimicrob. Agents Chemother 60:5182~5188
Lee S / 2011 / Rhamnetin production based on the rational design of the poplar O-methyltransferase enzyme and its biological activities / Bioorg. Med. Chem. Lett 21:3866~3870
Berardini N / 2005 / Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins and pectin / J. Agric. Food Chem. 53:1563~1570
Ramalho SD / 2015 / Evaluation of flavonols and derivatives as human cathepsin B inhibitor / Nat. Prod. Res 29:2212~2214
Qiu X / 2016 / Prophylactic efficacy of quercetin 3-β-OD-glucoside against Ebola virus infection / Antimicrob. Agents Chemother 60:5182~5188
Lee S / 2011 / Rhamnetin production based on the rational design of the poplar O-methyltransferase enzyme and its biological activities / Bioorg. Med. Chem. Lett 21:3866~3870
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Synthesis and Characterization of CdSe/CdS/N-Acetyl-L-Cysteine/Quercetin Nano-Composites and Their Antibacterial Performance
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Quercetin Attenuates the Production of Pro-Inflammatory Cytokines in H292 Human Lung Epithelial Cells Infected with Pseudomonas aeruginosa by Modulating ExoS Production
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Anti-tumor Effect of Quercetin in EBV-associated Human Gastric Carcinoma
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Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study
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Assessment of Antimicrobial Activity of Curcumin, Quercetin, and Resveratrol Against Diverse Microbial Strains
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The Anti-HSV Effect of Quercetin in Raw 264.7 Cells via Downregulation of Inflammatory Responses
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Effectiveness of Periodic Treatment of Quercetin against Viral Hemorrhagic Septicemia Virus
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