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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제4호
- 발행연도
- 2020.1
- 수록면
- 599 - 603 (5page)
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In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria Bifidobacterium adolescentis HP1, Lactobacillus mucosae HP2, and Weissella cibaria HP3 on high-fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain, triglycerides, and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and the fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, also suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most effectively. These findings suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.
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참고문헌 (17)
참고문헌 신청
Milić S / 2014 / Non-alcoholic fatty liver disease and obesity : biochemical, metabolic and clinical presentations / World J. Gastroenterol 20:9330~9337
Lee IS / 2010 / Shifts in diet from high fat to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high-fat diet / Endocrine J 57:39~50
Lira FS / 2012 / Both adiponectin and interleukin-10 inhibit LPSinduced activation of the NF-κB pathway in 3T3-L1 adipocytes / Cytokine 57:98~106
Jeong MY / 2019 / High-fat diet causes psychiatric disorders in mice by increasing Proteobacteria population / Neurosci. Lett 698:51~57
Kim KA / 2012 / High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway / PLoS One 7:e47713
Lee IS / 2010 / Shifts in diet from high fat to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high-fat diet / Endocrine J 57:39~50
Lira FS / 2012 / Both adiponectin and interleukin-10 inhibit LPSinduced activation of the NF-κB pathway in 3T3-L1 adipocytes / Cytokine 57:98~106
Jeong MY / 2019 / High-fat diet causes psychiatric disorders in mice by increasing Proteobacteria population / Neurosci. Lett 698:51~57
Kim KA / 2012 / High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway / PLoS One 7:e47713
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