지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제6호
- 발행연도
- 2019.1
- 수록면
- 361 - 368 (8page)
이용수
초록· 키워드
오류제보하기
Background: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. Management of GIST patients is currently based on clinicopathological features and associated genetic changes. However, the detailed characteristics and molecular genetic features of GISTs have not yet been described in the Vietnamese population. Methods: We first identified 155 patients with primary GIST who underwent surgery with primary curative intent between 2011 and 2014 at University Medical Center at Ho Chi Minh City, Vietnam. We evaluated the clinicopathological features and immunohistochemical reactivity to p53 and Ki-67 in these patients. Additionally, KIT genotyping was performed in 100 cases. Results: The largest proportion of GISTs was classified as high-risk (43.2%). Of the 155 GISTs, 52 (33.5%) were positive for Ki-67, and 58 (37.4%) were positive for p53. The expression of Ki-67 and p53 were correlated with mitotic rate, tumor size, risk assessment, and tumor stage. Out of 100 GIST cases, KIT mutation was found in 68%, of which 62 (91.2%) were found in exon 11, two (2.9%) in exon 9, and four (5.8%) in exon 17. No mutation in exon 13 was identified. Additionally, KIT mutations did not correlate with any clinicopathological features. Conclusions: The expression of Ki-67 and p53 were associated with high-risk tumors. Mutations in exon 11 were the most commonly found, followed by exon 17 and exon 9. Additionally, KIT mutation status was not correlated with any recognized clinicopathological features.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Miettinen M / 2010 / WHO classification of tumours of the digestive system / IARC :74~79
Søreide K / 2016 / Global epidemiology of gastrointestinal stromal tumours(GIST) : a systematic review of population-based cohort studies / Cancer Epidemiol 40:39~46
Mazur MT / 1983 / Gastric stromal tumors : reappraisal of histogenesis / Am J Surg Pathol 7:507~519
Hirota S / 1998 / Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors / Science 279:577~580
Joensuu H. / 2006 / Gastrointestinal stromal tumor (GIST) / Ann Oncol 17(Suppl 10):x280~x286
Søreide K / 2016 / Global epidemiology of gastrointestinal stromal tumours(GIST) : a systematic review of population-based cohort studies / Cancer Epidemiol 40:39~46
Mazur MT / 1983 / Gastric stromal tumors : reappraisal of histogenesis / Am J Surg Pathol 7:507~519
Hirota S / 1998 / Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors / Science 279:577~580
Joensuu H. / 2006 / Gastrointestinal stromal tumor (GIST) / Ann Oncol 17(Suppl 10):x280~x286
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma
Cancer Research and Treatment
2018 .01
-
Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea
Cancer Research and Treatment
2019 .01
-
Correlation between EGFR Gene Mutations and Lung Cancer: a Hospital-Based Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
C-kit Mutations in Endometrial Cancer: Correlation with Tumor Histologic Type
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Clinicopathological Analysis of Gastrointestinal Stromal Tumors for 18 Years
대한외과학회 학술대회 초록집
2018 .11
-
Genetic and clinical characteristics of Korean patients with neurofibromatosis type 2
Journal of genetic medicine
2017 .01
-
Congenital hypothyroidism due to thyroglobulin deficiency: a case report with a novel mutation in TG gene
Annals of Pediatirc Endocrinology & Metabolism
2019 .01
-
Role of exon 7 PTEN Gene in Endometrial Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Huge Steatocystoma Multiplex with New Point Mutation in the Exon 1 of KRT 17 Gene
Annals of Dermatology
2018 .01
-
A novel mutation in the DNMT1 gene in a patient presenting with pure cerebellar ataxia
Journal of genetic medicine
2017 .01
-
Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer
Cancer Research and Treatment
2017 .01
-
Novel Germline Mutations of BRCA1 and BRCA2 in Korean Familial Breast Cancer Patients
전남의대학술지
2019 .01
-
Incidence, Clinical Features, and Prognostic Impact of CALR Exon 9 Mutations in Essential Thrombocythemia and Primary Myelofibrosis: An Experience of a Single Tertiary Hospital in Korea
Annals of Laboratory Medicine
2015 .01
-
Incidences and Prognostic Impact of c-KIT, WT1, CEBPA, and CBL Mutations, and Mutations Associated With Epigenetic Modification in Core Binding Factor Acute Myeloid Leukemia: A Multicenter Study in a Korean Population
Annals of Laboratory Medicine
2015 .01
-
Robust home brew fragment sizing assay for detection of MET exon 14 skipping mutation in non?small cell lung cancer patients in resource constrained community hospitals
Journal of Pathology and Translational Medicine
2021 .09
-
Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
A Novel KIT INDEL Mutation in Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1
Annals of Laboratory Medicine
2016 .01
-
새로운 CPS1 유전자 돌연변이에 의한 신생아형 carbamoyl phosphate synthetase 1 결핍 1례
대한유전성대사질환학회지
2016 .01
-
A Novel MUT Gene Mutation Detected in a Female Infant with Methylmalonic Acidemia
Neonatal medicine
2015 .01
-
PCR-제한효소절편길이다형성법을 이용한 RHD 1227G＞A 및 1222T＞C 검출
대한수혈학회지
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0