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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제4호
- 발행연도
- 2020.1
- 수록면
- 265 - 275 (11page)
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초록· 키워드
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BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions of BRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics of BRCA-associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics of BRCA-associated breast cancer, incorporating findings on Asian patients.
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참고문헌 (103)
참고문헌 신청
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Ripperger T / 2009 / Breast cancer susceptibility : current knowledge and implications for genetic counselling / Eur J Hum Genet 17:722~731
Fackenthal JD / 2007 / Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations / Nat Rev Cancer 7:937~948
Ford D / 1998 / Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium / Am J Hum Genet 62:676~689
Antoniou A / 2003 / Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history : a combined analysis of 22 studies / Am J Hum Genet 72:1117~1130
Ripperger T / 2009 / Breast cancer susceptibility : current knowledge and implications for genetic counselling / Eur J Hum Genet 17:722~731
Fackenthal JD / 2007 / Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations / Nat Rev Cancer 7:937~948
Ford D / 1998 / Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium / Am J Hum Genet 62:676~689
Antoniou A / 2003 / Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history : a combined analysis of 22 studies / Am J Hum Genet 72:1117~1130
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