지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 181 - 192 (12page)
이용수
초록· 키워드
오류제보하기
Major depressive disorder (MDD) is a serious psychiatric illness that causes functional impairment in many people. While monoaminergic antidepressants have been used to effectively treat MDD, these antidepressants have limitations in that they have delayed onset of action and many patients remain treatment-resistant. Therefore, there is a need to develop antidepressants with a novel target, and researchers have directed their attention to the glutamatergic system. Ketamine, although developed as an anesthetic, has been found to produce an antidepressant effect at sub-anesthetic doses via N-Methyl-D-aspartic acid (NMDA) receptor blockade as well as NMDA receptor- independent pathways. A single infusion of ketamine produced rapid improvement in clinical symptoms to a considerable level and led to the resolution of serious depressive symptoms, including imminent suicidal ideation, in patients with MDD. A series of recent randomized controlled trials have provided a high level of evidence for the therapeutic efficacy of ketamine treatment in MDD and presented new insights on the dose, usage, and route of administration of ketamine as an antidepressant. With this knowledge, it is expected that ketamine treatment protocols for MDD will be established as a treatment option available in clinical practice. However, long-term safety must be taken into consideration as ketamine has abuse potential and it is associated with psychological side effects such as dissociative or psychotomimetic effects.
목차
등록된 정보가 없습니다.
참고문헌 (115)
참고문헌 신청
Ferrari AJ / 2013 / Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature / Psychol Med 43:471~481
Correll CU / 2017 / Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness : a large-scale meta-analysis of 3, 211, 768 patients and 113, 383, 368 controls / World Psychiatry 16:163~180
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps : a STAR*D report / Am J Psychiatry 163:1905~1917
Katz MM / 2004 / Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression / Neuropsychopharmacology 29:566~579
Machado-Vieira R / 2008 / Rapid onset of antidepressant action : a new paradigm in the research and treatment of major depressive disorder / J Clin Psychiatry 69:946~958
Correll CU / 2017 / Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness : a large-scale meta-analysis of 3, 211, 768 patients and 113, 383, 368 controls / World Psychiatry 16:163~180
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps : a STAR*D report / Am J Psychiatry 163:1905~1917
Katz MM / 2004 / Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression / Neuropsychopharmacology 29:566~579
Machado-Vieira R / 2008 / Rapid onset of antidepressant action : a new paradigm in the research and treatment of major depressive disorder / J Clin Psychiatry 69:946~958
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Ketamine의 속효성 항우울효과와 임상 적용
신경정신의학
2018 .01
-
Chronic administration of ketamine ameliorates the anxiety- and aggressive-like behavior in adolescent mice induced by neonatal maternal separation
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Comeback of ketamine: resurfacing facts and dispelling myths
Korean Journal of Anesthesiology
2021 .01
-
케타민의 항우울 효과와 임상적 적용
생물치료정신의학
2020 .06
-
Considerations for physicians using ketamine for sedation of children in emergency departments
Clinical and Experimental Emergency Medicine
2017 .01
-
Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine
The Korean Journal of Physiology & Pharmacology
2016 .11
-
A Case Report of Ketamine-induced Hypoglycemia in Treatment Resistance Depression
Clinical Psychopharmacology and Neuroscience
2024 .08
-
Factors Associated with Ketamine Use in Pancreatic Cancer Patient in a Single Hospice Center
한국호스피스·완화의료학회지
2016 .01
-
우울증 치료에서 빠른 효과와 적은 부작용을 가진 새로운 N-Methyl-D-Aspartate(NMDA) 수용체 길항제
생물정신의학
2015 .01
-
The First Case Report of Ketamine-Induced Cholangiopathy in Korea
대한췌담도학회지
2024 .01
-
The impact of ketamine on outcomes in critically ill patients: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials
Acute and Critical Care
2024 .02
-
Personalized Psychiatry and Depression: The Role of Sociodemographic and Clinical Variables
PSYCHIATRY INVESTIGATION
2020 .01
-
Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Ketamine use in the COVID-19 era: be cautious!
Korean Journal of Anesthesiology
2020 .01
-
Serum Cytokine Levels in Major Depressive Disorder and Its Role in Antidepressant Response
PSYCHIATRY INVESTIGATION
2016 .01
-
NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats
PSYCHIATRY INVESTIGATION
2020 .01
-
Pregnancy With a Successful Vaginal Delivery Following Augmentation Enterocystoplasty for Ketamine Cystitis: A Case Report
International Neurourology Journal
2016 .12
-
Efficacy and safety of low dose oral ketamine for controlling pain and distress during intravenous cannulation in children: a double-blind, randomized, placebo-controlled trial
The Korean Journal of Pain
2022 .07
-
Comparison of low-dose ketamine to methadone for postoperative pain in opioid addicts: a randomized clinical trial
Anesthesia and Pain Medicine
2024 .07
-
Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update
전남의대학술지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0